The effect of statin therapy on the progression of carotid artery stenosis in relation to stenosis severity

Acta Neurologica Scandinavica
O HeglandJ P Larsen

Abstract

To examine the effect of early statin treatment on progression of arteriosclerosis in internal carotid arteries (ICA); to compare the progression of arteriosclerosis in ICA of patients treated with a statin to the progression seen in drug-naïve patients. We performed repetitive Doppler scans of 363 carotid arteries with ICA stenosis > or =40% in 254 patients over time. Information on statin therapy and other risk factors for stroke were correlated with the annual change in degree of ICA stenosis. In statin-treated patients, 19% of ICA stenosis showed a progression while 74% showed a regression of stenosis. In statin-naïve patients, 63% of stenotic arteries showed a progression, while a reduction could be observed in 28%. Decrease of ICA stenosis was most accentuated in patients with a mild stenosis and was independent of serum cholesterol levels. Treatment with statins already in early stages of ICA stenosis might delay the progression and even reverse the degree of stenosis.

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Citations

Jun 1, 2012·Stroke; a Journal of Cerebral Circulation·Jose G Romano, David S Liebeskind
Jan 31, 2012·Annals of Vascular Surgery·Christopher A DurhamMichael C Stoner
Jul 2, 2011·Seminars in Vascular Surgery·Caron Rockman, Shang Loh
Oct 29, 2010·Acta Neurologica Scandinavica·D K Y ChanW T Hung
May 23, 2012·Acta Neurologica Scandinavica·I Momjian-MayorR F Sztajzel
Nov 12, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Min WuLongtao Liu
Apr 18, 2015·European Heart Journal·John Kjekshus
Nov 26, 2010·Vascular and Endovascular Surgery·Zeeshan MalikAlun H Davies
Feb 21, 2019·The Journal of Cardiovascular Surgery·Kamran Gaba, Richard Bulbulia

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