The effect of statins on sympathetic activity: a meta-analysis

Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society
Jacek LewandowskiMaciej Siński

Abstract

Beyond lipid-lowering properties, statins decrease sympathetic nervous activity. Due to the limited number of studies and included participants, a meta-analysis of randomized, placebo-controlled studies using microneurography (MSNA) was performed to assess sympatholytic effect of statins. We conducted a comprehensive search of online databases (Cochrane, Embase, and EBSCO) for published human studies up to April 2014. Randomized controlled trials (parallel and crossover design) were eligible for inclusion if results of statins versus placebo treatments on sympathetic activity were measured with MSNA. Data from five studies with a total number of subjects n = 82 were included into the meta-analysis. MSNA expressed as bursts/min and as bursts/100 heartbeats was lower in the statin group than in the placebo group with a mean difference of -4.37 95% CI (-7.03; -1.70), p < 0.0013 and -5.85 95% CI (-7.56; -4.13), p < 0.0001, respectively. No significant publication bias was observed. Meta-regression revealed no significant effect of baseline total cholesterol or dose of statin. No change in blood pressure and heart rate was observed. Published data show that regardless of type and dose, statins reduce sympathetic activity measured by...Continue Reading

References

Aug 25, 1999·Journal of Hypertension·G Grassi, M Esler
Aug 7, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Sam RiahiErik Berg Schmidt
Jul 31, 2003·The American Journal of Cardiology·Vojtech MelenovskyMarek Malik
Apr 12, 2005·Annual Review of Pharmacology and Toxicology·James K Liao, Ulrich Laufs
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Dec 5, 2009·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Marc E GomesCees J Tack
Jul 30, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Jacek LewandowskiZbigniew Gaciong
Oct 19, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Marc E GomesJacques W M Lenders
Nov 23, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Takuya Kishi, Yoshitaka Hirooka
Sep 8, 2011·Journal of Hypertension·Laima SiddiqiPeter J Blankestijn
May 12, 2012·Neoplasia : an International Journal for Oncology Research·Agata MalendaDominika A Nowis
Jun 5, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Shekhar H DeoPaul J Fadel
Apr 23, 2013·International Journal of Cardiology·Maciej BanachUNKNOWN Lipid and Blood Pressure Meta-Analysis Collaboration Group
Apr 26, 2013·The Journal of Clinical Hypertension·Alexandros BriasoulisFranz H Messerli
Nov 28, 2013·Clinical Science·Philip J Millar, John S Floras
Nov 25, 2014·Journal of the American Society of Hypertension : JASH·Jacek LewandowskiZbigniew Gaciong

❮ Previous
Next ❯

Citations

Nov 3, 2016·American Journal of Epidemiology·Olta GishtiRomy Gaillard
Aug 3, 2017·International Journal of Molecular Sciences·Jasdeep KaurPaul J Fadel
May 10, 2019·JAMA Otolaryngology-- Head & Neck Surgery·Dorina KallogjeriJay F Piccirillo
Jun 13, 2019·Hypertension·Benjamin E YoungPaul J Fadel
May 9, 2019·Hypertension·Elisabeth A LambertGavin W Lambert
Oct 15, 2019·Journal of the American Heart Association·Adam D GepnerCynthia M Carlsson
Apr 4, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Jeung-Ki YooQi Fu
Jul 23, 2020·European Journal of Clinical Pharmacology·Jahad AlghamdiSandosh Padmanabhan
Nov 10, 2020·Archives of Endocrinology and Metabolism·Roberta de Pádua BorgesMarcello Casaccia Bertoluci
Aug 7, 2021·Journal of Cardiovascular Development and Disease·Nasim KiaieAmirhossein Sahebkar
Aug 3, 2021·EMBO Molecular Medicine·Elena SommarivaGiulio Pompilio
Aug 14, 2021·European Journal of Nuclear Medicine and Molecular Imaging·David M RaffelKirk A Frey
Sep 17, 2021·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Keisuke ShinoharaHiroyuki Tsutsui

❮ Previous
Next ❯

Software Mentioned

meta
MSNA
R package
metafor

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the American Society of Nephrology : JASN
Sabrina SandhuMarcello Tonelli
American Journal of Physiology. Heart and Circulatory Physiology
Shekhar H DeoPaul J Fadel
© 2022 Meta ULC. All rights reserved