The Effect of Statins on the Functionality of CD4+CD25+FOXP3+ Regulatory T-cells in Acute Coronary Syndrome: A Systematic Review and Meta-analysis of Randomised Controlled Trials in Asian Populations

European Cardiology
Nilofer SorathiaBenham Zal

Abstract

Acute coronary syndrome (ACS) is characterised by increased effector cells and decreased regulatory T-cells (Tregs). Statins have been shown to be clinically beneficial in ACS patients. This effect could be mediated via the induction of Tregs in ACS patients. The aim of this systemic review and meta-analysis was to evaluate whether statin therapy enhances the frequency of Tregs determined by CD4+CD25+FOXP3+ in this subset of patients. A comprehensive search of PubMed and Embase was performed. Studies were restricted to randomised controlled trials that quantified CD4+CD25+FOXP3+ cell frequency by flow cytometric analysis before and after statin treatment in adults diagnosed with ACS. A minimum of at least two of the conventional markers to identify Tregs was compulsory. Four randomised controlled trials studies (439 participants) were included, all with low-to-moderate risk of bias. Pooled data showed a significant increase in Treg frequency after statin therapy in ACS patients. A further meta-regression and subgroup analysis also showed a negative dose-related effect, and a statin type-related effect (rosuvastatin versus atorvastatin), respectively. The results confirmed that statins positively alter the frequency of Tregs, wh...Continue Reading

References

Sep 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·E P AmentoP Libby
Mar 1, 1986·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·L JonassonG K Hansson
Jul 1, 1984·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·D W MorelG M Chisolm
Sep 3, 1998·The Journal of Biological Chemistry·U Laufs, J K Liao
Jan 12, 2001·Physiological Reviews·Y TakaiT Matozaki
Apr 13, 2001·JAMA : the Journal of the American Medical Association·G G SchwartzUNKNOWN Myocardial Ischemia Reduction with Aggressive Cholesterol Lowering (MIRACL) Study Investigators
Jun 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K M Thorstenson, A Khoruts
Jul 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C Baecher-AllanD A Hafler
Mar 27, 2003·Nature Reviews. Immunology·Matthias G von Herrath, Leonard C Harrison
Oct 28, 2003·Nature Immunology·Francesca FallarinoPaolo Puccetti
Nov 5, 2003·The Journal of Clinical Investigation·Mindi R WalkerSteven F Ziegler
Jul 29, 2004·The Journal of Experimental Medicine·Michael R EhrensteinClaudia Mauri
Sep 1, 2004·JAMA : the Journal of the American Medical Association·James A de LemosUNKNOWN Investigators
Mar 24, 2005·Human Immunology·Leonie S TaamsFloris P J G Lafeber
Apr 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Marc A GavinAlexander Y Rudensky
Dec 13, 2006·European Journal of Immunology·Jun WangRené E M Toes
Dec 22, 2006·European Journal of Immunology·Steven F Ziegler
May 22, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Shu-fang HanGuo-liang Jia
Sep 11, 2007·Atherosclerosis·Karin Mausner-FainbergJacob George
Nov 23, 2007·Nature·Lauren W CollisonDario A A Vignali
Dec 7, 2007·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Zhenping HuKeping Yang
Mar 15, 2008·Critical Pathways in Cardiology·Kausik K Ray, Christopher P Cannon
Apr 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bitao LiangRaphael Clynes
Oct 4, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Behnam ZalChristina Baboonian
Feb 11, 2009·Archives of Internal Medicine·Varda ShalevAnthony D Heymann
Mar 13, 2012·Biochemical and Biophysical Research Communications·N BerghS Jern

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Citations

May 16, 2020·Mediators of Inflammation·César Daniel Sánchez-HernándezAlberto N Peón
Jul 31, 2019·European Cardiology·Pablo Avanzas

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Methods Mentioned

BETA
geranylgeranylation
fluorescence-activated cell sorting

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