The effect of steroids on the biophysical profile and Doppler indices of umbilical and middle cerebral arteries in healthy preterm fetuses

European Journal of Obstetrics, Gynecology, and Reproductive Biology
Deren OR O Bahado-Singh

Abstract

To examine the effect of antenatal steroids on the biophysical profile and the Doppler parameters of umbilical and middle cerebral arteries of healthy fetuses. Thiry-five singleton pregnancies between the gestational ages of 28 and 34 weeks, who received two consecutive doses of betamethasone 24h apart to accelerate pulmonary maturation were prospectively studied. Fetal biophysical profile and Doppler assessment were performed at 0 (pre-steroid), 24, 48, 72, 96 and 120 h after the administration of first dose. We compared the percentage of the fetuses with biophysical parameters present for each of the five components of the biophysical profile and the Doppler indices, using Cochran's Q-test, Friedman's test and one way analysis of variance of repeated measures where appropriate. The statistical significance was defined as P<0.05. The mean delivery time was 36.9(+/-1.8) weeks. There was a statistically significant difference in the frequency of the following findings in the pre- compared to post-steroid measurements: absence of body movements (48 h, P<0.05), non-reassuring fetal heart rate tracings (24, 48 and 72 h, P<0.05) and absence of breathing movements (24, 48 and 72 h, p<0.05). Initially none of the biophysical profile s...Continue Reading

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Citations

Feb 22, 2002·Prenatal Diagnosis
Jun 1, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Remigiusz UrbanMałgorzata Kretowska
Apr 22, 2005·Journal of Perinatal Medicine·Burcu Saygan-KaramurselTekin Durukan
Sep 13, 2006·Journal of Perinatal Medicine·Gian Carlo Di RenzoUNKNOWN European Association of Perinatal Medicine-Study Group on Preterm Birth
Mar 1, 2011·Clinics in Perinatology·Yinka Oyelese, Anthony M Vintzileos
Jun 22, 2010·European Journal of Obstetrics, Gynecology, and Reproductive Biology·N Cenk SayinNecdet Süt
Dec 9, 2008·Seminars in Fetal & Neonatal Medicine·E J H MulderG H A Visser
Jan 25, 2005·BJOG : an International Journal of Obstetrics and Gynaecology·Josine S QuaedackersLaura Bennet
May 17, 2014·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·O B UstunyurtN Danisman
Nov 15, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ilhan Bahri DelibasOmer Erkan Yapca
Jun 2, 2004·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·L D E WijnbergerG H A Visser
Feb 7, 2008·The Cochrane Database of Systematic Reviews·J G LalorD Devane
Mar 28, 2006·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·S GucluA A Baschat
Aug 1, 2013·Australasian Journal of Ultrasound in Medicine·Amanda HenryAlec Welsh
Jul 26, 2018·Neuroscience and Biobehavioral Reviews·Julia J MüllerMatthias Schwab

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