The effect of striatal dopamine depletion on striatal and cortical glutamate: A mini-review

Progress in Neuro-psychopharmacology & Biological Psychiatry
Fernando CaravaggioAriel Graff-Guerrero

Abstract

Understanding the interplay between the neurotransmitters dopamine and glutamate in the striatum has become the highlight of several theories of neuropsychiatric illnesses, such as schizophrenia. Using in vivo brain imaging in humans, alterations in dopamine and glutamate concentrations have been observed in several neuropsychiatric disorders. However, it is unclear a priori how alterations in striatal dopamine should modulate glutamate concentrations in the basal ganglia. In this selective mini-review, we examine the consequence of reducing striatal dopamine functioning on glutamate concentrations in the striatum and cortex; regions of interest heavily examined in the human brain imaging studies. We examine the predictions of the classical model of the basal ganglia, and contrast it with findings in humans and animals. The review concludes that chronic dopamine depletion (>4months) produces decreases in striatal glutamate levels which are consistent with the classical model of the basal ganglia. However, acute alterations in striatal dopamine functioning, specifically at the D2 receptors, may produce opposite affects. This has important implications for models of the basal ganglia and theorizing about neurochemical alterations...Continue Reading

References

Oct 1, 1989·Trends in Neurosciences·R L AlbinJ B Penney
Jun 27, 1997·Brain Research·P W Kalivas, P Duffy
Sep 1, 1997·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M LaruelleR B Innis
Feb 22, 2001·Trends in Neurosciences·M P NusbaumE Marder
May 2, 2001·Parkinsonism & Related Disorders·S Rayport
Jun 27, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·N P VerhoeffR B Zipursky
Feb 15, 2005·Magnetic Resonance Imaging·Josef PfeufferNikos K Logothetis
Oct 2, 2007·NMR in Biomedicine·H Randall GriffithJan A den Hollander
Oct 3, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Cristina NanniDomenico Rubello
Nov 29, 2007·Brain Research Reviews·Laurent DescarriesLouis-Eric Trudeau
May 30, 2008·Pharmacology, Biochemistry, and Behavior·Alberto Del Arco, Francisco Mora
Sep 19, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sabrina BouletLéon Tremblay
Oct 22, 2009·The Journal of Comparative Neurology·Noémie Bérubé-CarrièreLaurent Descarries
Jul 7, 2010·Neuroscience and Biobehavioral Reviews·Michael T Treadway, David H Zald
Jul 28, 2010·NMR in Biomedicine·Carine ChassainFranck Durif
Mar 19, 2011·Nature Reviews. Neuroscience·Salah El MestikawyLouis-Eric Trudeau
Apr 22, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Camilo de la Fuente-SandovalAriel Graff-Guerrero
Aug 3, 2011·Frontiers in Neuroanatomy·José A Obeso, José L Lanciego
Jun 22, 2012·The International Journal of Neuropsychopharmacology·Camilo de la Fuente-SandovalAriel Graff-Guerrero
Feb 15, 2014·Current Opinion in Pharmacology·Marc Laruelle
Aug 28, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Eric PlitmanAriel Graff-Guerrero
Mar 31, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Fernando CaravaggioAriel Graff-Guerrero
Apr 2, 2015·Indian Journal of Nuclear Medicine : IJNM : the Official Journal of the Society of Nuclear Medicine, India·Jayanta DasSoumendranath Ray
Jul 3, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tobias GleichJürgen Gallinat

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Citations

Jul 9, 2016·Progress in Neurobiology·Philippe De DeurwaerdèreMark J Millan
Oct 28, 2016·Arthritis & Rheumatology·Federica DelunardoPaola Margutti
Jun 4, 2019·Neuropharmacology·Sri Mahavir AgarwalMargaret Hahn
May 23, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Beatrice OrsoMatteo Pardini

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