The Effect of Stromal Integrin β3-Deficiency on Two Different Tumors in Mice

Cancers
Inga ReigstadLinda B Stuhr

Abstract

There is an increasing focus on the tumor microenvironment in carcinogenesis. Integrins are important receptors and adhesion molecules in this environment and have been shown to be involved in cell adhesion, proliferation, differentiation and migration. The present study aimed to evaluate the effect of stromal integrin β3-deficiency on tumor growth, angiogenesis, interstitial fluid pressure (PIF), fibrosis and metastasis in a murine breast cancer (4T1) and a prostate tumor (RM11) model. We showed that stromal integrin β3-deficiency led to an elevation in PIF that correlated to a shift towards thicker collagen fibrils in the 4T1 mammary tumor. In the RM11 prostate carcinoma model there was no effect of integrin β3-deficiency on PIF and collagen fibril thickness. These findings support the notion that changes in the collagen scaffold influence PIF, and also indicate that there must be important crosstalk between the stroma and tumor cells, in a tumor cell line specific manner. Furthermore, stromal integrin β3-deficiency had no effect on tumor growth or angiogenesis in both tumor models and no effect on lung metastasis in the 4T1 mammary tumor model. In conclusion, the stromal β3 integrin influence PIF, possibly via its effect on ...Continue Reading

References

Oct 1, 1987·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·J R Levick
Jan 1, 1986·Annals of Biomedical Engineering·H WiigK Aukland
Oct 1, 1995·The Journal of Clinical Investigation·P C BrooksD A Cheresh
Jan 23, 1999·The Journal of Clinical Investigation·K M Hodivala-DilkeR O Hynes
Feb 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·B Felding-HabermannB M Mueller
Mar 16, 2001·Breast Cancer Research : BCR·G H HeppnerP M Shekhar
Jan 12, 2002·Nature Medicine·Louise E ReynoldsKairbaan M Hodivala-Dilke
Sep 6, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alexei V SalnikovKristofer Rubin
Nov 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Suzanne J BakewellKatherine N Weilbaecher
Jan 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Daniela TavernaRichard O Hynes
Jun 1, 2004·Clinical & Experimental Metastasis·John F HarmsDavid W Griggs
Jun 1, 2004·Clinical & Experimental Metastasis·Kristen E ShannonDavid W Griggs
Oct 29, 2004·Nature Reviews. Cancer·Carl-Henrik HeldinArne Ostman
Mar 31, 2006·Nature Reviews. Cancer·Raghu Kalluri, Michael Zeisberg
Oct 5, 2006·Anti-cancer Agents in Medicinal Chemistry·Weibo Cai, Xiaoyuan Chen
Aug 24, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ake OldbergKristofer Rubin
Nov 5, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David A ReardonL Burt Nabors
Mar 10, 2009·Angiogenesis·Payaningal R SomanathTatiana V Byzova
Jun 13, 2009·Current Cancer Drug Targets·H M Sheldrake, L H Patterson
Dec 24, 2009·Nature Reviews. Cancer·Jay S Desgrosellier, David A Cheresh
Jan 1, 2008·Drug Development Research·Zhaofei LiuXiaoyuan Chen
Jan 25, 2011·Nature Reviews. Cancer·Laurie J Gay, Brunhilde Felding-Habermann
Feb 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Benjamin Diop-FrimpongRakesh K Jain
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Jun 7, 2012·Melanoma Research·Kevin B KimA Dimitrios Colevas
Sep 13, 2012·Molecular Pharmaceutics·Fabienne DanhierVéronique Préat
Jul 11, 2014·Anti-cancer Drugs·Cui-Cui SunZu-Hua Gao
Apr 16, 2015·Oncology Reports·Maureen PickarskiLe T Duong

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Citations

Jun 10, 2017·Expert Review of Anticancer Therapy·Parnaz MerikhianKeivan Majidzadeh-A
Jul 1, 2019·The Journal of the Acoustical Society of America·Saurabh RautKenneth Hoyt

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Methods Mentioned

BETA
light microscopy
transmission electron microscopy
Scanning Electron Microscopy

Software Mentioned

GraphPad
Fiji
Graph Pad Prism
Image J
Sigmaplot

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