PMID: 43662Jan 1, 1979

The effect of sulfasalazine and its active components on human polymorphonuclear leukocyte function in relation to ulcerative colitis

Acta Medica Scandinavica
L Molin, O Stendahl

Abstract

Sulfasalazine and its active components, 5-aminosalicylic acid (5-ASA) and sulfapyridine (SP), are potent modulators of inflammatory reactions but with somewhat different modes of action. Investigating the effect of these compounds on normal human polymorphonuclear leukocytes in vitro, we show inhibition of different stages in the phagocytic process, such as migration (sulfasalazine and SP), superoxide production (sulfasalazine and SP), myeloperoxidase-mediated iodination and cytotoxicity (5-ASA and SP). It is thus suggested that sulfasalazine is not just a vehicle for delivering its active components in the colon, but that its therapeutic effect is ulcerative colitis and other inflammatory reactions is a result of the concurrent action of the three compounds.

References

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Citations

Nov 1, 1976·Clinical Pharmacokinetics·K M Das, R Dubin
Mar 23, 1978·The New England Journal of Medicine·B M Babior
May 31, 1975·Lancet·M Ward, J P McManus
Jun 1, 1974·The Journal of Clinical Investigation·J T Curnutte, B M Babior
Jul 1, 1972·Clinical Pharmacology and Therapeutics·H Schröder, D E Campbell

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