PMID: 43662Jan 1, 1979

The effect of sulfasalazine and its active components on human polymorphonuclear leukocyte function in relation to ulcerative colitis

Acta Medica Scandinavica
L Molin, O Stendahl


Sulfasalazine and its active components, 5-aminosalicylic acid (5-ASA) and sulfapyridine (SP), are potent modulators of inflammatory reactions but with somewhat different modes of action. Investigating the effect of these compounds on normal human polymorphonuclear leukocytes in vitro, we show inhibition of different stages in the phagocytic process, such as migration (sulfasalazine and SP), superoxide production (sulfasalazine and SP), myeloperoxidase-mediated iodination and cytotoxicity (5-ASA and SP). It is thus suggested that sulfasalazine is not just a vehicle for delivering its active components in the colon, but that its therapeutic effect is ulcerative colitis and other inflammatory reactions is a result of the concurrent action of the three compounds.


Jan 1, 1987·Acta Medica Scandinavica·S BondesenE F Hvidberg
Feb 1, 1984·Digestive Diseases and Sciences·B SaffouriJ E Gardiner
Apr 1, 1989·Digestive Diseases and Sciences·M B Grisham, D N Granger
Dec 1, 1987·Digestive Diseases and Sciences·B M PeskarH Goebell
Dec 1, 1987·Clinical Rheumatology·N FelteliusO Sjöberg
Jan 1, 1990·Scandinavian Journal of Gastroenterology. Supplement·S B Hanauer
Jan 1, 1989·International Journal of Colorectal Disease·K LauritsenJ Rask-Madsen
Jun 16, 2005·Journal of Gastroenterology and Hepatology·Hua-Tian GanQin Ouyang
Mar 4, 2015·Scandinavian Journal of Gastroenterology·Øyvind HausoHelge Waldum
Aug 1, 1991·Scandinavian Journal of Gastroenterology·H HornH Ditschuneit
Jan 1, 1991·Scandinavian Journal of Gastroenterology. Supplement·H W VerspagetC B Lamers
Mar 1, 1987·Annals of the Rheumatic Diseases·H J EnglertM J Walport
Dec 1, 1985·Digestive Diseases and Sciences·C J HawkeyB J Whittle
May 1, 1991·Gut·J Hayllar, I Bjarnason
Mar 1, 1988·Digestive Diseases and Sciences·M B Grisham, D N Granger
Jul 18, 2009·Expert Opinion on Pharmacotherapy·Michael G FeelyJames R O'Dell
Jan 18, 2013·Digestive Diseases·Volker Gross
Nov 1, 1990·International Journal of Dermatology·A K GuptaJ J Voorhees
Mar 21, 2001·Critical Reviews in Clinical Laboratory Sciences·Richard J FarrellMark A Peppercorn
Jul 4, 2002·The American Journal of Gastroenterology·Richard J Farrell, Mark A Peppercorn
May 11, 2012·Digestive Diseases·Volker Gross
Jan 7, 2011·Redox Report : Communications in Free Radical Research·Diana CoutoEduarda Fernandes
Jun 1, 1992·Digestive Diseases and Sciences·T S Gaginella, R E Walsh


Nov 1, 1976·Clinical Pharmacokinetics·K M Das, R Dubin
Mar 23, 1978·The New England Journal of Medicine·B M Babior
May 31, 1975·Lancet·M Ward, J P McManus
Jun 1, 1974·The Journal of Clinical Investigation·J T Curnutte, B M Babior
Jul 1, 1972·Clinical Pharmacology and Therapeutics·H Schröder, D E Campbell

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