The effect of superoxide dismutase enzyme inhibition on renal microcirculation of spontaneously hypertensive-stroke prone and Wistar rats

Physiological Research
Ahmad F AhmedaEdward J Johns

Abstract

A significant factor in the development of hypertension may be excessive vasoconstriction within the renal medulla. This study therefore investigated the role of superoxide dismutase (SOD) in the regulation of renal medullary and cortical blood perfusion (MBP and CBP, respectively) in both stroke-prone spontaneously hypertensive rats (SHRSP) and normotensive Wistar rats. CBP and MBP were measured before and after intra-renal infusion of the SOD inhibitor, diethyldithio-carbamic acid (DETC). Under basal conditions, mean arterial pressure was significantly greater in SHRSP than Wistar rats, but both MBP and heart rate (HR) were significantly lower in SHRSP relative to Wistar rats (P<0.05, n=7 in both groups). Infusion of DETC (2 mg/kg/min) into the cortico-medullary border area of the kidney significantly decreased MBP in the SHRSPs (by 28+/-3 %, n=7, P<0.05), indicating a greater vasoconstriction within this vascular bed. However, DETC also significantly decreased MBP in Wistar rats to a similar extent (24+/-4 %, n=7, P<0.05). These results suggest that superoxide anions play a significant role in reducing renal vascular compliance within the renal medulla in both normotensive and hypertensive animals, although the responses are...Continue Reading

References

May 1, 1986·Archives of Biochemistry and Biophysics·B Halliwell, J M Gutteridge
Sep 1, 1981·The American Journal of Physiology·A NagaokaK Hamajo
Mar 1, 1980·The American Journal of Physiology·K H BerecekF Gross
Apr 1, 1995·Hypertension·A W CowleyR J Roman
May 1, 1993·Biochemical Society Transactions·J S Beckman, J P Crow
Oct 27, 1998·Molecular and Cellular Biochemistry·T ChakrabortiS Chakraborti
Oct 16, 1999·Hypertension·J A HaasJ C Romero
Mar 7, 2001·Hypertension·A P ZouA W Cowley
Feb 16, 2002·Hypertension·Dewan S A Majid, Akira Nishiyama
Jun 7, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ya-Fei ChenAi-Ping Zou
Mar 1, 1963·Japanese Circulation Journal·K OKAMOTO, K AOKI
Dec 14, 2011·Clinical and Experimental Pharmacology & Physiology·Takefumi MoriSadayoshi Ito
Jul 26, 2013·American Journal of Physiology. Renal Physiology·Nicholas G MossWilliam J Arendshorst
Dec 24, 2014·International Journal of Molecular Sciences·Marius C StaiculescuLuis A Martinez-Lemus
Jun 15, 2016·Saudi Journal of Biological Sciences·Ahmad F Ahmeda, Mohammed Alzoghaibi

❮ Previous
Next ❯

Citations

Oct 28, 2019·Physiological Research·J ZichaI Vaněčková

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.