The effect of suppressive thyroxine therapy in nodular goiter in postmenopausal women and 2 year's bone mineral density change

Endocrine Journal
Chiung-Ya ChenFeng-Hsuan Liu

Abstract

The efficacy of thyroxine suppressive therapy in reducing nodular growth and its effect to bone mineral density (BMD) in postmenopausal women is still debated. This study aimed to evaluate the therapeutic effect of thyroxine and its influence on BMD. Postmenopausal women with nodular or multinodular goiter during 2013-2015 at Chang Gung Memorial Hospital were enrolled and retrospectively traced back to the first date of visit or treatment. Ninety-four eligible patients were enrolled, of whom 45 were thyroxine-treated (LT-4 group) and 49 were treatment-naïve (control group). Data, including volume of nodules, were analyzed retrospectively. BMD was measured in each LT-4 group patient since the year of enrollment. Nodular volumes were reduced in both LT-4 (from 4.89 ± 4.46 to 4.10 ± 4.57 mL, p = 0.033) and control group (3.48 ± 4.36 to 3.09 ± 2.88 mL, p = 0.239) at initial 2-year follow-up. Nodular volume in LT-4 group increased insignificantly (from 4.89 ± 4.46 to 4.91 ± 5.40 mL, p = 0.711) at the end of 7-year follow-up. The best cut-off predictive nodular volume that may have responded to thyroxine is 2.6 mL (AUC, 0.740; sensitivity, 0.750; specificity, 0.733) during first 2 year. Lumbar spine, total hip and femoral neck BMD we...Continue Reading

References

May 15, 1971·Lancet·S A FraserG M Wilson
Apr 1, 1995·Thyroid : Official Journal of the American Thyroid Association·C G MüllerR Tsang
Jul 1, 1994·World Journal of Surgery·K KumaM Sugawara
Feb 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L J Melton
Nov 10, 1994·The New England Journal of Medicine·C T SawinR B D'Agostino
Nov 1, 1995·Journal of Endocrinological Investigation·E MaininiC Mazzi
Feb 12, 1998·Thyroid : Official Journal of the American Thyroid Association·N LimaG Medeiros-Neto
Jan 1, 1997·Fundamental & Clinical Pharmacology·P NonyJ P Boissel
Mar 7, 1998·Annals of Internal Medicine·H Gharib, E L Mazzaferri
Jun 4, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·B L RiggsL J Melton
May 29, 2000·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A Kanis, C C Glüer
Sep 6, 2002·The Journal of Clinical Endocrinology and Metabolism·M Regina CastroJohn C Morris
Oct 25, 2002·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·B QuadbeckR Hoermann
Feb 15, 2003·Annals of Internal Medicine·Erik K AlexanderEllen Marqusee
Aug 15, 2003·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Marco GalloRoberto Valcavi
Oct 1, 2003·Trends in Endocrinology and Metabolism : TEM·J H Duncan Bassett, Graham R Williams
Jan 15, 2004·JAMA : the Journal of the American Medical Association·Martin I SurksNeil J Weissman
Sep 15, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Olof Johnell, John Kanis
Jan 1, 1950·Cancer·W J YOUDEN
Dec 28, 2007·The Journal of Clinical Endocrinology and Metabolism·Joel S FinkelsteinRobert M Neer
Dec 5, 2008·Journal of the American Geriatrics Society·Graziano CeresiniLuigi Ferrucci
Jun 25, 2009·Journal of Medical Virology·Sheng-Fan WangYi-Ming Arthur Chen
Oct 23, 2009·American Journal of Clinical Pathology·Edmund S CibasUNKNOWN NCI Thyroid FNA State of the Science Conference
Jul 6, 2010·Archives of Biochemistry and Biophysics·Apostolos I GogakosGraham R Williams
Aug 5, 2010·Endocrine Journal·Roberto CesareoEnrico Di Stasio
Apr 25, 2012·Archives of Internal Medicine·Tinh-Hai ColletUNKNOWN Thyroid Studies Collaboration
Feb 2, 2013·Endocrine, Metabolic & Immune Disorders Drug Targets·Baris GencerNicolas Rodondi
Mar 1, 2013·European Thyroid Journal·Massimiliano AndrioliLuca Persani
Jul 11, 2014·Journal of Endocrinological Investigation·Alessandro PuzzielloMario Vitale
Dec 2, 2014·International Journal of Hypertension·Shu C ChenHsien W Kuo
Mar 4, 2015·JAMA : the Journal of the American Medical Association·Cosimo DuranteSebastiano Filetti
May 27, 2015·JAMA : the Journal of the American Medical Association·Manuel R BlumUNKNOWN Thyroid Studies Collaboration
Aug 15, 2015·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Kam-Tsun TangYao-Te Hsieh
Jan 25, 2018·Open Access Macedonian Journal of Medical Sciences·Milena Cojić, Ljiljana Cvejanov-Kezunović

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