The effect of supraphysiologic levels of iodine on patients with cyclic mastalgia

The Breast Journal
Jack H Kessler

Abstract

A randomized, double-blind, placebo-controlled, multicenter clinical trial was conducted with 111 otherwise healthy euthyroid women with a history of breast pain. Patients had to document moderate or severe breast pain by recording a score > or =5 on a visual analog scale (VAS) of pain for > or =6 days per cycle and had to present with fibrosis involving at least 25% of both breast surfaces. Subjects could not be effectively treated with more conservative measures such as local heat or nonprescription analgesics. There was not a statistically significant difference in the dropout rate for patients on placebo (11.8%), 1.5 mg/day (31.3%), 3.0 mg/day (18.4%), or 6.0 mg/day (25%) of molecular iodine for 6 months. Physicians assessed breast pain, tenderness, and nodularity each cycle; patients assessed breast pain and tenderness with the Lewin breast pain scale at 3-month intervals and with a VAS at each cycle. A statistically significant improvement (p < 0.01) associated with dose was observed in the Lewin overall pain scale for all treated groups compared to placebo. Reductions in all three physician assessments were observed in patients after 5 months of therapy in the 3.0 mg/day (7/28; 25%) and 6.0 mg/day (15/27; 18.5%) treatmen...Continue Reading

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Citations

Feb 6, 2007·Thyroid : Official Journal of the American Thyroid Association·Jack Kessler, Dan Hooge
Oct 25, 2007·Thyroid : Official Journal of the American Thyroid Association·Brenda AnguianoCarmen Aceves Velasco
Jan 18, 2006·The Breast Journal·Giorgio Maria Baratelli
Jul 23, 2008·International Journal of Medical Sciences·Frederick R StoddardGregg J Johannes
Jul 16, 2014·Prostaglandins & Other Lipid Mediators·Mario Nava-Villalba, Carmen Aceves
Feb 11, 2015·Thyroid : Official Journal of the American Thyroid Association·Guadalupe DelgadoCarmen Aceves
Jan 31, 2021·International Journal of Molecular Sciences·Carmen AcevesEvangelina Delgado-González

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