PMID: 7017403Apr 1, 1981Paper

The effect of surface membrane modifications of fibroblastic cells on the entry process of Trypanosoma cruzi trypomastigotes

Molecular and Biochemical Parasitology
D HenriquezM M Piras

Abstract

Treatment prior to infection with Trypanosoma cruzi trypomastigotes of Vero, MA-103, and chick muscle cells with concanavalin A, phytohemagglutinin, wheat germ agglutinin and ricin I results in a diminished parasite interiorization in these cells; succinylated concanavalin A is also inhibitory. The effect of these lectins is abolished by the corresponding sugar haptens. Trypsin and periodate treatment of the cells also inhibits infection, as well as calcium ionophore A23187 and drugs that disrupt microtubules and microfilaments directly, like colchicine, vinblastine and cytochalasin B. These results show that alteration(s) of a surface glycoprotein(s) and/or of the plasma membrane architecture of fibroblastic host cells inhibit infection, suggesting that the surface membrane of these cells does not play a passive role in the process of infection by T. cruzi.

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Citations

Jun 1, 1984·International Journal for Parasitology·A OsunaM C Mascaro
Oct 1, 1995·International Journal for Parasitology·A OsunaM C Mascaró
Jan 1, 1983·Transactions of the Royal Society of Tropical Medicine and Hygiene·J M Blackwell, J Alexander
Jan 1, 1985·Transactions of the Royal Society of Tropical Medicine and Hygiene·D Snary
May 1, 1982·Molecular and Biochemical Parasitology·M S Crane, J A Dvorak
Nov 1, 1985·Molecular and Biochemical Parasitology·M C Connelly, F Kierszenbaum
Apr 1, 1985·Molecular and Biochemical Parasitology·J J Wirth, F Kierszenbaum
Jun 1, 1985·Molecular and Biochemical Parasitology·F Villalta, F Kierszenbaum
Jan 15, 1987·Molecular and Biochemical Parasitology·F Villalta, F Kierszenbaum
Feb 1, 1987·Molecular and Biochemical Parasitology·A Ayala, F Kierszenbaum
May 30, 1985·Biochimica Et Biophysica Acta·F Villalta, F Kierszenbaum
Aug 30, 1988·Biochemical and Biophysical Research Communications·M F Lima, F Villalta
Feb 1, 1996·Parasitology·A HemphillH Kaufmann
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·F KierszenbaumA Sjoerdsma
Sep 3, 2010·International Journal of Cell Biology·Wanderley de SouzaEmile Santos Barrias
Feb 9, 2002·Journal of Cellular Biochemistry·Barbara SpadilieroDiana A Henríquez
Sep 24, 2009·Memórias do Instituto Oswaldo Cruz·Maria Julia Manso Alves, Renato Arruda Mortara
Feb 29, 1984·Biochemical and Biophysical Research Communications·F Villalta, F Kierszenbaum
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Nov 1, 1985·European Journal of Immunology·M A OuaissiA Capron
Jan 1, 1990·Infection and Immunity·C D Davis, R E Kuhn
Dec 7, 1983·Biochimica Et Biophysica Acta·F Villalta, F Kierszenbaum
Jun 29, 1984·Biochemical and Biophysical Research Communications·M C Connelly, F Kierszenbaum
Nov 27, 1981·Science·J A Dvorak, M S Crane

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