The effect of surgery and pretreatment or posttreatment adjuvant chemotherapy on primary tumor growth in an animal model.

Journal of Surgical Oncology
M J StrausS C Choi

Abstract

The Ca755 solid tumor in the C57B1 mouse has been used as a model to study the interrelationship of surgery and adjuvant chemotherapy on primary tumor growth. Surgery was performed on various days after tumor implantation. Surgical mortality increased with delay in surgery. The mean survival time (MST) was significantly increased by surgery. An increased cure rate in mice with late surgery may be due to immunological factors. Pretreatment cytoxan chemotherapy prior to a number of surgical days on the most effect schedule increased MST in the later surgical days primarily due to shrinkage of tumor and a diminished surgical mortality. Posttreatment chemotherapy significantly increased MST primarily on the basis of reducing tumor cell population after surgery and increasing both the cure rate and the time until death of those mice dying of regrowth of tumor. Optimal chemotherapy alone significantly increased MST compared to untreated controls. Optimal postsurgery chemotherapy increased survival longer than the additive increase of chemotherapy alone and surgery alone. This paper illustrates relationships between day of surgery dose and schedule of chemotherapy and effect on various measurable parameters. The results can best be un...Continue Reading

References

Feb 1, 1973·Journal of the National Cancer Institute·M J StrausA Goldin
Mar 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·M J Straus, A Goldin
Aug 1, 1971·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K W BrunnerW Müller
May 15, 1967·International Journal of Cancer. Journal International Du Cancer·K KarrerA Goldin

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