Abstract
Mild primary hyperparathyroidism has been associated with increased body fat mass and unfavorable cardiovascular risk factors. To assess the effect of parathyroidectomy on fat mass, glucose and lipid metabolism. Design, Patients, Interventions, Main outcome measures: 119 patients previously randomized to observation (OBS; n=58) or parathyroidectomy (PTX; n=61) within the Scandinavian Investigation of Primary Hyperparathyroidism (SIPH) trial, an open randomized multicenter study, were included. Main outcome measures for this study were the differences in fat mass, markers for lipid- and glucose metabolism between OBS and PTX five years after randomization. In the OBS group, total cholesterol (Total-C) decreased from mean 5.9 (±1.1) to 5.6 (±1.0) mmol/l (P=0.037) and LDL-Cholesterol (LDL-C) decreased from 3.7 (±1.0) to 3.3 (±0.9) mmol/l (P=0.010). In the PTX group, the Total-C and LDL-C remained unchanged resulting in a significant between group difference over time (P=0.013 and P=0.026, respectively). This difference was driven by patients who started with lipid lowering medication during the study period (OBS: 5; PTX: 1). There was an increase in trunk fat mass in the OBS group, but no between group differences over time. Mean ...Continue Reading
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