PMID: 786351Oct 1, 1975

The effect of suxamethonium alone and its interaction with gallamine on the indirectly elicited tetanic and single twitch contractions of skeletal muscle in man during anaesthesia

British Journal of Clinical Pharmacology
N SugaiJ P Payne

Abstract

Simultaneous measurements of tetanic and single twitch contractions of the adductor politics muscle in man were made during neuromuscular blockade induced by suxamethonium (0.2 mg/kg) under nitrous oxide, oxygen and pentazocine anaesthesia. 2. After a suitable control period, suxamethonium (0.2 mg/kg) was given intravenously and the same dose was repeated 15 min later. After a further 15 min gallamine (0.2 mg/kg) was administered intravenously. When recovery from gallamine reached a plateau on the tetanic contraction recording a third injection of suxamethonium was given. 3. In most patients, suxamethonium (0.2 mg/kg) caused a partial blockade of the single twitch and complete blockade of the tetanic contraction. In every instance, the tetanic contraction was more depressed and recovered more slowly than the single twitch which not only recovered promptly but also showed overshoot. 4. After gallamine marked antagonism to suxamethonium block developed and this was greater with the single twitch than with the tetanic contractions. 5. Tetanic-tension fade was observed after every injection of suxamethonium and the degree of fade was dependent on the frequency of the tetanic stimulation.

References

May 1, 1971·Anesthesiology·A Galindo
Oct 1, 1969·Anaesthesia·M F Tyrrell
Aug 1, 1960·British Journal of Anaesthesia·H C CHURCHILL-DAVIDSON, R P WISE
Feb 1, 1963·British Journal of Pharmacology and Chemotherapy·J G BLACKMAN
Apr 1, 1965·British Journal of Pharmacology and Chemotherapy·J J JONES, J L LAITY
Feb 1, 1951·The Journal of Physiology·W D M PATON, E J ZAIMIS
Sep 1, 1951·The Journal of Physiology·B D BURNS, W D M PATON

Citations

Jan 1, 1976·Canadian Anaesthetists' Society Journal·R HughesN Sugai
May 1, 1979·British Journal of Clinical Pharmacology·R Hughes, J P Payne
Feb 1, 1981·Acta Anaesthesiologica Scandinavica·G G CokerR D Waigh
Mar 1, 1982·British Journal of Clinical Pharmacology·R HughesJ P Payne

Related Concepts

Anesthesia Procedures
Clinical Trials
Depression, Chemical
Drug Interactions
Gallamine
Inotropism
Nitrous Oxide
Dioxygen
Talwin

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