The effect of swelling on TRH and oxytocin secretion from hypothalamic structures.

Cellular and Molecular Neurobiology
Z BačováV Strbák

Abstract

1. Cell swelling induces exocytosis of material stored in secretory vesicles resulting in a secretory burst of peptidic hormones or enzymes from various types of cells including endocrine cells and neurons. We have previously shown that swelling-induced exocytosis possesses limited selectivity; hypotonic medium evokes TRH but not oxytocin release from hypothalamic paraventricular nucleus (PVN) and neurohypophysis (NH). 2. It is the aim of this study to ascertain whether the swelling-induced oxytocin secretion could be unmasked by the inhibition of specific osmotic response using Ca(2+)-free medium and GdCl(3), an inhibitor of stretch activated channels. 3. Oxytocin release from the PVN was stimulated by the hypotonic medium only in the presence of 50 or 100 microM GdCl(3.) Oxytocin release from supraoptic nucleus (SON) was also stimulated by the Ca(2+)-free hypotonic medium in the presence of GdCl(3). Oxytocin secretion from the NH was not stimulated even in the presence of GdCl(3), both in Ca(2+) containing and Ca(2+)-free medium. TRH response to swelling-inducing stimulus was not affected by the presence of GdCl(3). 4. An intranuclear oxytocin secretion to hyposmotic stimulation within the PVN and the SON could be unmasked by...Continue Reading

References

Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Jan 1, 1997·Annual Review of Physiology·C W Bourque, S H Oliet
Jul 1, 1997·Trends in Pharmacological Sciences·A R Wright, S A Rees
Jan 14, 2000·European Journal of Endocrinology·J Benický, V Strbák
Aug 3, 2000·Alcoholism, Clinical and Experimental Research·T K KnottS N Treistman
Dec 23, 2000·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·V Strbák, M A Greer
Feb 15, 2002·Pflügers Archiv : European journal of physiology·F P ThinnesN Hilschmann
Mar 22, 2003·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Miroslava NajvirtováVladimír Strbák
Feb 26, 2005·The Journal of Physiology·Mike LudwigGareth Leng
Aug 3, 2005·Cellular and Molecular Neurobiology·Bing-Jun ZhangHarold Gainer

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Citations

Feb 27, 2008·Journal of Cellular Physiology·Rodrigo FrancoLenin D Ochoa de la Paz
Dec 20, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Vladimír Strbák

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