The effect of synbiotic on glycemic profile and sex hormones in overweight and obese breast cancer survivors following a weight-loss diet: A randomized, triple-blind, controlled trial.

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
Mahsa Raji LahijiMitra Zarrati

Abstract

The investigation was designed to assess the effects of synbiotic supplementation on glycemic profile, insulin-like growth factor-1 (IGF-1) and sex hormones in overweight and obese postmenopausal breast cancer survivors (BCSs) who had hormone-receptor-positive breast cancer. This randomized, triple-blind, placebo-controlled trial was conducted on 76 overweight and obese BCSs aged 57.43 (5.82) years. All participants were given a specified low calorie diet and were randomly assigned into two groups to intake 109 CFU/day of synbiotic supplement (n = 38) or placebo (n = 38) for 8 weeks. Body composition, physical activity, glycemic profile, IGF-1, estradiol, testosterone and dehydroepiandrosterone sulfate (DHEA-S) were measured at baseline and after 8 weeks. A significant reduction in serum insulin (median change (Q1, Q3) from baseline of -1.05 (-2.36, 0.32) μIU/mL; P = 0.006) and insulin resistance (HOMA-IR) (mean change (SD) from baseline of -4.0 (0.9); P = 0.007) were seen over the 8 weeks in the synbiotic group. However, no significant changes were observed in serum insulin, fasting plasma glucose, HbA1c, HOMA-IR, IGF-1, estradiol, testosterone, DHEA-S and sex hormone binding globulin between-groups at the end of the intervent...Continue Reading

References

Jan 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·M PugeatJ Tourniaire
May 1, 1984·The American Journal of Clinical Nutrition·B R Goldin, S L Gorbach
Feb 1, 1980·Journal of the National Cancer Institute·B R GoldinS L Gorbach
Feb 7, 2001·The American Journal of Clinical Nutrition·J Schrezenmeir, M de Vrese
Sep 7, 2001·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·T FlötottoM W Beckmann
Jan 5, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pamela J GoodwinNicky Hood
Aug 6, 2003·Medicine and Science in Sports and Exercise·Cora L CraigPekka Oja
Aug 3, 2004·Nature Reviews. Cancer·Eugenia E Calle, Rudolf Kaaks
Feb 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Melinda L IrwinRachel Ballard-Barbash
Jul 21, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kathryn H SchmitzDouglas Yee
Mar 1, 2007·European Journal of Clinical Nutrition·V De PreterK Verbeke
Mar 8, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Cheryl L RockUNKNOWN Women's Healthy Eating and Living Study Group
Mar 19, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shaheenah DawoodMassimo Cristofanilli
Nov 26, 2008·Journal of Mammary Gland Biology and Neoplasia·Danielle Lann, Derek LeRoith
Mar 2, 2010·International Journal of Food Sciences and Nutrition·Manoj KumarHariom Yadav
Dec 1, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Melinda L IrwinRachel Ballard-Barbash
Dec 14, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pamela J GoodwinNicky Hood
Dec 27, 2011·Breast Cancer Research and Treatment·Christie A BefortCarol J Fabian
Jun 15, 2012·Journal of Pediatric Gastroenterology and Nutrition·Rikke Juul GøbelKim Fleischer Michaelsen
Jul 31, 2012·Journal of Cancer Research and Therapeutics·Reza NuriHamid Emami
Aug 1, 2012·International Journal of Cancer. Journal International Du Cancer·Catherine DugganAnne McTiernan
Nov 14, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Karen P ScottSylvia H Duncan
Jun 22, 2013·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Zatollah AsemiAhmad Esmaillzadeh
Oct 25, 2013·Journal of Mammary Gland Biology and Neoplasia·Valentina BelardiDerek LeRoith
Nov 14, 2013·Journal of Mammary Gland Biology and Neoplasia·Rishi JainJoseph A Sparano
Mar 13, 2014·Applied and Environmental Microbiology·Camilla UrbaniakGregor Reid
Apr 29, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D S M ChanT Norat
Jun 18, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Melinda L Irwin
Oct 2, 2015·Journal of the National Cancer Institute·Mary C PlaydonMelinda L Irwin
Oct 16, 2015·Scientific Reports·Sagarika BanerjeeErle S Robertson
Jan 7, 2016·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Livia Bordalo TonucciHercia Stampini Duarte Martino
Feb 13, 2016·Breast Cancer Research and Treatment·Catherine DugganAnne McTiernan
May 28, 2016·Integrative Cancer Therapies·Nur Rizi ZamberiNoorjahan Banu Alitheen
Jun 22, 2016·Scientific Reports·Alfred A ChanDelphine J Lee
Jun 28, 2016·Applied and Environmental Microbiology·Camilla UrbaniakGregor Reid

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