The effect of synbiotics on acute radiation-induced diarrhea and its association with mucosal inflammatory and adaptive responses in rats

Digestive Diseases and Sciences
Basileios G SpyropoulosVasileios Kouloulias


Previous clinical studies advocated that probiotics beneficially affect acute radiation-induced diarrhea. These encouraging results were attributed to the restoration of the intestinal flora; however, there is lack of evidence if and how probiotics influence the underlying pathophysiological mechanisms. The present study was conducted to investigate the potential supporting role of a synbiotic preparation (combination of pro- and pre-biotics) on experimentally-induced acute radiation diarrhea from the perspective of mucosal inflammation and histological injury. Ninety adult Wistar rats were randomly assigned into six groups. Group A (non-irradiated), group B (non-irradiated/synbiotic supplemented), group C (irradiated), and group D (irradiated/synbiotic supplemented) were followed up to a week after the beginning of the experiment. Group E (irradiated) and group F (irradiated/synbiotic supplemented) were followed up for four days. On the last day of the experiments tissues were harvested for structural and molecular assessments. Synbiotic administration could not avert the occurrence of diarrhea, but significantly attenuated its severity. This effect was associated with the significant downregulation of neutrophil accumulation ...Continue Reading


Jan 1, 1992·Free Radical Biology & Medicine·C F Babbs
Feb 9, 1989·The New England Journal of Medicine·S J Weiss
Feb 1, 1989·The Journal of Surgical Research·G Guzman-SteinJ P Delaney
Aug 1, 1987·The British Journal of Surgery·R B Galland, J Spencer
Apr 1, 1986·World Journal of Surgery·D H Smith, J J DeCosse
Jan 1, 1993·Clinical Oncology : a Journal of the Royal College of Radiologists·C A BaughanR M Pickering
Jul 1, 1997·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M ResbeutT D N'Guyen
Dec 17, 1997·Scandinavian Journal of Gastroenterology·G S HowarthE K Yeoh
Feb 13, 2001·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C PicardN M Griffiths
Sep 25, 2001·Micron : the International Research and Review Journal for Microscopy·Z SomosyZ Pálfia
Dec 4, 2001·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·W Dörr, J H Hendry
Jun 14, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·James W Denham, Martin Hauer-Jensen
Jul 20, 2002·Free Radical Biology & Medicine·Kevin P PavlickMatthew B Grisham
Aug 23, 2002·The American Journal of Gastroenterology·Pietro DeliaGiuseppe Famularo
Sep 14, 2002·Current Gastroenterology Reports·Mike M Bismar, Frank A Sinicrope
Nov 26, 2002·Clinical and Experimental Medicine·K KisielinskiV Schumpelick
Mar 20, 2003·The Journal of Surgical Research·Jing-Min HwangLih-Min Tsai
Sep 1, 2005·Life Sciences·Yeşim ErbilGülçin Toker
Oct 11, 2005·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Laura E MatareseEzra Steiger
Feb 7, 2006·Nutrition·Seher DemirerSercin Karahüseyinoglu
Jun 20, 2006·The Journal of Surgical Research·Mehmet KeskekMahmut Koc
Aug 29, 2006·World Journal of Gastroenterology : WJG·Laurie Drozdowski, Alan B R Thomson
Mar 14, 2007·World Journal of Gastroenterology : WJG·P DeliaG Famularo
Jun 15, 2007·World Journal of Gastroenterology : WJG·Mary F Otterson
Jun 26, 2007·World Journal of Gastroenterology : WJG·Meritxell Molla, Julian Panes
Jun 26, 2007·World Journal of Gastroenterology : WJG·Junru WangMartin Hauer-Jensen
Jul 26, 2007·Journal of Digestive Diseases·Mg SealF Marotta
Aug 11, 2007·International Journal of Colorectal Disease·Cristina F DiestelMargareth C Portela
Nov 24, 2007·International Journal of Radiation Oncology, Biology, Physics·Sandra TorresAgnès François
May 29, 2008·Journal of the National Cancer Institute·Brian D LawendaJeffrey B Blumberg
Dec 26, 2008·World Journal of Gastroenterology : WJG·Jannis Kountouras, Christos Zavos
Jun 23, 2009·Annals of the New York Academy of Sciences·Matthew A Ciorba, William F Stenson
Nov 10, 2009·Clinical Oncology : a Journal of the Royal College of Radiologists·V S TheisS Lal
Dec 31, 2009·Current Opinion in Gastroenterology·Christopher D Packey, Matthew A Ciorba
Jul 16, 2010·Digestive Diseases and Sciences·Basileios G SpyropoulosChristos N Stoidis

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Paediatric Dentistry
Svante Twetman, Christina Stecksén-Blicks
Nihon rinsho. Japanese journal of clinical medicine
Takeshi KamiyaTakashi Joh
Nihon rinsho. Japanese journal of clinical medicine
Hideko IizukaToshifumi Hibi
Vojnosanitetski pregled. Military-medical and pharmaceutical review
Slobodan ObradovićBranko Gligić
Frontiers in Bioscience : a Journal and Virtual Library
Borja SanchezAbelardo Margolles
© 2022 Meta ULC. All rights reserved