The effect of systemic corticosteroids on the innate and adaptive immune system in children with steroid responsive nephrotic syndrome

European Journal of Pediatrics
Hatice Ezgi BarisIsil Barlan

Abstract

The severity and duration of immunosuppression caused by corticosteroids (CSs) usage have not been extensively studied. We aimed to investigate the effects of CSs on the various compartments of immune system in relation to timing of initiation and persistence of therapy. Pediatric patients with idiopathic nephrotic syndrome (NS) treated with 2 mg/kg/day prednisolone and healthy control (HC) were enrolled. Blood samples were drawn for immunologic analyses at baseline and at the first and second weeks and first, second, and third months of CS therapy in addition to first and second weeks and first, second, and third months of discontinuation. Fourteen patients (M/F, 7/7) between 1 and 8 years old were evaluated. Untreated NS exhibited high absolute lymphocyte count (ALC)(p = 0.010), absolute CD3(+) T cells (p = 0.020) and absolute CD8(+) T cells (p = 0.006) compared to HC. Suppression in ALC was observed and nadir value was noted at first month of therapy compared to baseline (p = 0.002). The CD4(+) (p = 0.036) and CD8(+) T cell (p = 0.013) counts decreased significantly at the first week of treatment compared to baseline. While baseline B cell counts was indifferent from HC, gradually increased in 2 weeks of CS initiation and de...Continue Reading

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Citations

Jan 23, 2020·American Journal of Respiratory Cell and Molecular Biology·Saleela M RuwanpuraPhilip G Bardin
Mar 10, 2020·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Yang LiuHuadong Zhu
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May 21, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Maryam RameshradHossein Hosseinzadeh
Jan 13, 2018·Journal of the American Society of Nephrology : JASN·Eva SchrezenmeierThomas Dörner
Jun 6, 2021·The Journal of Allergy and Clinical Immunology·SuJin HwangSergio D Rosenzweig

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