PMID: 7523907Oct 1, 1994Paper

The effect of T-lymphocyte 'clonality' on the calculated hprt mutation frequency occurring in vivo in humans

Mutation Research
J P O'NeillR J Albertini

Abstract

The frequency of 6-thioguanine resistant (TGr) mutant T-lymphocytes arising in vivo in humans can be quantified with a cell cloning assay. However, the in vivo proliferation of T-lymphocytes that may include TGr mutant cells can distort the relationship between mutation events and the resulting frequency of mutant cells. The T-cell receptor (TCR) gene rearrangement pattern of T-cell colonies can be used as an independent measure of clonality. Analysis of T-cell 'clonality' in 413 wild type and 1736 TGr mutant isolates from 58 individuals shows that mutant clonality is a frequent occurrence (35/58 individuals = 60.3%). However, a major effect on the mutant frequency corrected for clonality (the calculated 'mutation frequency') was found only in nine samples all of which had mutant frequencies greater than 40 x 10(-6).

References

Sep 1, 1990·Mutagenesis·L RecioR J Albertini
Apr 1, 1989·The Journal of Experimental Medicine·M HakodaM Akiyama
Jan 1, 1989·Environmental and Molecular Mutagenesis·J P O'NeillR J Albertini
Mar 10, 1983·Nature·A A MorleyR G Ryall
Nov 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·R J AlbertiniW R Borcherding

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Citations

Jan 1, 1994·Environmental and Molecular Mutagenesis·R J Albertini
Mar 1, 1995·Mutation Research·R F Branda, R J Albertini
Dec 1, 1995·Toxicology Letters·B LambertS M Hou
Aug 1, 1998·Mutation Research·R J AlbertiniJ P O'Neill
Apr 21, 1999·Mutation Research·L Risom, L E Knudsen
Oct 12, 2000·Mutation Research·M KubotaY Wakazono
Nov 17, 2007·Environmental and Molecular Mutagenesis·Sachin V BendreRobert H Heflich
Aug 21, 2008·Environmental and Molecular Mutagenesis·Mark R AlbertiniRichard J Albertini
May 12, 2005·Environmental and Molecular Mutagenesis·Patrick O'NeillRichard Albertini
Jan 1, 1996·Environmental and Molecular Mutagenesis·H NishinoS S Sommer
Jul 12, 2002·Environmental and Molecular Mutagenesis·M A VickersM Hewitt
Mar 4, 2005·Environmental and Molecular Mutagenesis·Mark AllegrettaRichard J Albertini

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