PMID: 15379424Sep 24, 2004Paper

The effect of tamoxifen on sex hormone binding globulin in adolescents with pubertal gynecomastia

Journal of Pediatric Endocrinology & Metabolism : JPEM
Orhan DermanTülay E Tokur

Abstract

We investigated the relationship between sex hormone binding globulin (SHBG) and pubertal gynecomastia in 21 adolescents evaluated longitudinally. Thirteen patients were given tamoxifen treatment after grading according to the Nydick classification (group 1). Group 2 consisted of eight patients followed without treatment. Gynecomastia existed bilaterally in 15 patients. There was a statistically significant breast size reduction in both groups. There was a significant decrease in serum SHBG only in group 2. These findings suggest that serum SHBG is increased by tamoxifen treatment in male adolescents. There was a decrease in SHBG levels through the duration of follow up in patients who recovered with or without treatment. However, this decrease was statistically significant in the untreated group, but not in the tamoxifen treated group. In conclusion, we suggest that the pubertal fall in SHBG levels is attenuated by tamoxifen treatment given for pubertal gynecomastia since tamoxifen increases SHBG levels in male adolescents.

References

Mar 1, 1990·The Journal of Pediatrics·F M BiroJ A Morrison
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May 1, 1986·Clinical Endocrinology·B EstourH Rousset
Feb 1, 1970·Archives of Disease in Childhood·W A Marshall, J M Tanner
May 1, 1984·The Journal of Clinical Endocrinology and Metabolism·S K CunninghamT J McKenna
Jan 1, 1996·Hormone Research·M PugeatM G Forest
Jan 1, 1997·Hormone Research·R Mathur, G D Braunstein

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Citations

May 7, 2016·Andrology·E WibowoR J Wassersug
Jun 10, 2017·International Journal of Adolescent Medicine and Health·Sinem AkgülNuray Kanbur
Jun 5, 2013·Journal of Pediatric Endocrinology & Metabolism : JPEM·Oren LapidLeon Perlemuter

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