PMID: 2508386Sep 1, 1989Paper

The effect of tamoxifen on the function and lifespan of the corpus luteum and on subsequent ovarian function

Acta Endocrinologica
M L SwahnZ Y Wu

Abstract

The aim of the present study was to investigate the effects of tamoxifen on pituitary and luteal function and on the bleeding pattern when administered continuously in the secretory phase. The study included 16 women with regular menstrual cycles followed during one control, one treatment and one follow-up cycle. Each volunteer received 20 mg tamoxifen twice daily from cycle day 18 to menstruation in the treatment cycle. The luteal phase was slightly, but significantly prolonged during treatment, and FSH, progesterone, 17-hydroxyprogesterone, 20 alpha- dihydro progesterone, estrone, estrone sulphate and estradiol significantly elevated in comparison with corresponding data during the control cycle. The results indicate that estrogen may be of some importance for the regulation of the life span of the corpus luteum in the human. The significantly elevated levels of pregnanediol glucuronide and estrone glucuronide during the follow-up cycle are most likely a result of either a direct effect of remaining circulating tamoxifen levels on the ovary, or mediated through the increased release of FSH. If estrogens are of importance for the process of implantation, which has recently been suggested in sub-human primates, also in the huma...Continue Reading

Citations

Jan 1, 1991·Preventive Medicine·V C Jordan
May 1, 1992·Current Problems in Cancer·V C Jordan
Jul 26, 2015·Breast Cancer Research and Treatment·A Jo ChienMitch P Rosen
Nov 4, 2000·The Journal of Clinical Endocrinology and Metabolism·C H ChiangP C Leung

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