PMID: 6540181Jun 1, 1984Paper

The effect of tamoxifen on the growth of human malignant melanoma in vitro

European Journal of Cancer & Clinical Oncology
P G GillD J Horsfall

Abstract

The effect of tamoxifen on the growth of malignant melanoma was investigated using human cell lines and single-cell suspensions prepared from patients' tumours cultured in soft agar. Tamoxifen stimulated both [3H]-thymidine incorporation and cell numbers in all of the cell lines tested. Cytoplasmic oestrogen receptor (ER) was detected in one of the responding lines and progesterone receptor (PR) in another. Tumour colony formation in soft agar culture was satisfactorily established from tumour cell suspensions from 13 of 21 patients, only one of which had detectable cytoplasmic ER. Greater than 50% reduction in colony formation with 5 X 10(-7) M tamoxifen occurred in two tumours, neither of which contained ER. These results indicate that tamoxifen has the potential to either retard or accelerate the growth of human malignant melanoma.

References

Aug 14, 1976·Lancet·R I FisherM E Lippman
Apr 1, 1979·Pathology·J H Pope Regius Mary Sister
Nov 29, 1979·The New England Journal of Medicine·R A NesbitM Goodyear
Aug 1, 1978·Cancer·H M ShawW H McCarthy
Aug 1, 1976·The Australian and New Zealand Journal of Surgery·N DavisJ Little
Apr 1, 1980·Journal of Steroid Biochemistry·W D TilleyV R Marshall
May 1, 1981·British Journal of Cancer·A J ThompsonP G Gill
Sep 15, 1980·Cancer·K S McCartyH F Seigler
Jun 1, 1980·The Journal of Investigative Dermatology·J P Neifeld, M E Lippman
Sep 1, 1980·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R L Sutherland, L C Murphy
Mar 1, 1980·Archives of Surgery·K E StedmanR T Morgan
Feb 1, 1980·British Journal of Cancer·A E BatemanG D Towse
Apr 1, 1980·British Journal of Cancer·P RümkeC B Korsten
Oct 15, 1980·Cancer·E T CreaganN S Jiang
Aug 1, 1980·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J C Allegra, M E Lippman
Jan 1, 1980·Cancer Chemotherapy and Pharmacology·P WilkinsonJ Patterson

❮ Previous
Next ❯

Citations

Jul 5, 2006·Cancer Research·Takuji MoriDave S B Hoon
Jul 1, 1997·American Journal of Respiratory Cell and Molecular Biology·S CaltagironeM Piantelli
Jan 5, 2010·Steroids·T S Karin Eisinger-MathasonDeborah A Lannigan
Jul 15, 2015·European Journal of Pharmacology·Mariana P C RibeiroJosé B A Custódio
May 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology· VijayalaxmiTerence S Herman
Dec 16, 2003·Skinmed·Jabob Mashiah, Sarah Brenner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.