The effect of tamsulosin on the resting tone and the contractile behaviour of the female urethra: a functional urodynamic study in healthy women

European Urology
André ReitzBrigitte Schurch

Abstract

The aim of this functional urodynamic experiment was to study the effect of the selective alpha1(A)-blocker tamsulosin on the urethral pressure in healthy human females and assessed first the resting urethral pressure and second the urethral contractility in response to magnetic stimulation of the sacral roots. 11 healthy female subjects gave their written informed consent and were included. A microtip pressure transducer catheter was inserted into the bladder and three baseline urethral pressure profiles were obtained. Another three urethral pressure profiles were recorded while magnetic single pulse stimulation of the sacral roots was performed above the motor threshold of the pelvic floor to evoke reproducible urethral contractions. Then the subjects received 0.4 mg of tamsulosin and the entire protocol was repeated 6 hours after drug administration. Cardiovascular monitoring was obtained during the baseline and follow-up measurements. Mean and maximal urethral pressure values calculated over the entire urethra, mean pressure values calculated over the proximal, middle and distal third of the urethra and the pressure amplitudes to magnetic stimulation at baseline were statistically compared to the follow-up measurements with...Continue Reading

Citations

Nov 5, 2008·International Urogynecology Journal and Pelvic Floor Dysfunction·A AthanasopoulosP Perimenis
Nov 25, 2006·International Urology and Nephrology·Sara Ramsey, Michael Palmer
May 19, 2005·Journal of Cataract and Refractive Surgery·David F Chang, John R Campbell
Dec 17, 2015·Nature Reviews. Urology·Karl-Erik Andersson
Sep 14, 2010·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·X Gamé, C-J Fowler
Nov 26, 2008·Journal of Cataract and Refractive Surgery·David F ChangUNKNOWN ASCRS Cataract Clinical Committee
Aug 30, 2008·International Journal of Urology : Official Journal of the Japanese Urological Association·Shang-Jen ChangHong-Jeng Yu
Mar 16, 2006·The Journal of Pharmacy and Pharmacology·Akiyoshi OhtakeKeiji Miyata
Sep 6, 2006·The Journal of Urology·Thomas M KesslerFiona C Burkhard
Apr 21, 2016·Expert Opinion on Drug Metabolism & Toxicology·Joshua A CohnRoger R Dmochowski
May 1, 2012·Current Urology·Faruquz ZamanNoor Buchholz
Jun 10, 2018·The Journal of Pharmacology and Experimental Therapeutics·Kazuyuki SakamotoNoriyuki Masuda
Nov 13, 2018·Female Pelvic Medicine & Reconstructive Surgery·Graham C ChapmanJeffrey M Mangel
Mar 21, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xiang XieWeiqun Yu
Jul 11, 2020·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·F TahaS Larre

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