The Effect of Temperature Increases on Brain Tissue Oxygen Tension in Patients with Traumatic Brain Injury: A Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury Substudy.

Therapeutic Hypothermia and Temperature Management
Verena RassCENTER-TBI HR ICU Investigators and Participants

Abstract

Fever may aggravate secondary brain injury after traumatic brain injury (TBI). The aim of this study was to identify episodes of temperature increases through visual plot analysis and algorithm supported detection, and to describe associated patterns of changes in on brain tissue oxygen tension (PbtO2). Data derive from the high-resolution cohort of the multicenter prospective Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI) study. Temperature increases (≥0.5°C) were visually identified in 33 patients within the first 11 days of monitoring. Generalized estimating equations were used to detect significant changes of systemic and neuromonitoring parameters from baseline to the highest temperature. Patients were median 50 (interquartile range [IQR], 35-62) years old, and presented with a Glasgow Coma Scale (GCS) of 8 (IQR, 4-10). In 202 episodes of temperature increases, mean temperature rose by 1.0°C ± 0.5°C within 4 hours. Overall, PbtO2 slightly increased (ΔPbtO2 = 0.9 ± 6.1 mmHg, p = 0.022) during temperature increases. PbtO2 increased in 35% (p < 0.001), was stable in 49% (p = 0.852), and decreased in 16% (p < 0.001) of episodes. During episodes of temperature increases and simultaneous drops in P...Continue Reading

References

Dec 1, 1987·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R BustoM D Ginsberg
Oct 3, 2000·Neurosurgery·M M KilpatrickD W Marion
Sep 19, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·S RossiN Stocchetti
Mar 5, 2004·The Journal of Neuroscience Nursing : Journal of the American Association of Neuroscience Nurses·Laura Mcilvoy
Jul 19, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·N StocchettiE R Zanier
Apr 17, 2008·Neurosurgery·Alejandro M SpiottaPeter D Le Roux
Aug 30, 2008·Stroke; a Journal of Cerebral Circulation·David M GreerGwen C Uman
Mar 14, 2014·Frontiers in Physiology·Anthony R BainPhilip N Ainslie
Jul 15, 2016·Critical Care : the Official Journal of the Critical Care Forum·Edward James WalterLui Forni
Sep 23, 2016·Neurosurgery·Nancy CarneyJamshid Ghajar
Nov 15, 2017·Critical Care Medicine·Ahmad Abu-ArafehPeter J D Andrews
Oct 3, 2018·Journal of Neurosurgical Anesthesiology·Edoardo PicettiFabio Silvio Taccone

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Citations

Feb 5, 2021·Minerva anestesiologica·Franco CavalierePierpaolo Terragni

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NCT02210221

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