The effect of teriparatide to alleviate pain and to prevent vertebral collapse after fresh osteoporotic vertebral fracture

Journal of Bone and Mineral Metabolism
Hiroyuki TsuchieYoichi Shimada

Abstract

Vertebral fracture is often seen in osteoporotic patients. Teriparatide is expected to promote bone union. Therefore, we evaluated the action of vertebral collapse prevention by administering teriparatide to vertebral fracture patients. Thirty-four patients with fresh vertebral fracture (48 vertebrae) participated in this study. They were administered either teriparatide (daily 20 µg/day or weekly 56.5 µg/week) or risedronate (17.5 mg/week): ten patients (20 vertebrae) received teriparatide daily (Daily group), 11 patients (15 vertebrae) received teriparatide weekly (Weekly group), and 13 patients (14 vertebrae) received risedronate (RIS group). We compared some laboratory examination items, visual analogue scale (VAS) of low back pain, vertebral collapse rate and local kyphotic angle, and the cleft frequency. In addition, we evaluated 22 vertebral fracture patients (24 vertebrae) who did not take any osteoporotic medicines (Control group). There was no significant difference in any of the scores at the start of treatment. At 8 and 12 weeks after the initial visit, VAS scores in the Daily and Weekly groups were significantly lower than in the RIS group (p < 0.05). At 8 and 12 weeks, the vertebral collapse rate and local kyphoti...Continue Reading

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Citations

Sep 1, 2016·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·Akira IwataNorimasa Iwasaki
Feb 27, 2019·Clinical Spine Surgery : a Spine Publication·Nathan WandermanBrett Freedman
Dec 20, 2017·Spine Surgery and Related Research·Sumihisa OritaSeiji Ohtori
Aug 20, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H-K MinJ-H Cho
Jul 13, 2019·Journal of Bone and Mineral Metabolism·Satoshi IkedaUNKNOWN KOTU T-WRAP Study Investigators
Aug 22, 2015·Case Reports in Orthopedics·Naohisa MiyakoshiYoichi Shimada
Mar 20, 2020·Journal of Bone Metabolism·Young Ho ShinJi Wan Kim
Jan 31, 2021·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Hiroyuki InoseAtsushi Okawa
Feb 10, 2021·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K EastmanW Fraser

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