The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men

The Journal of Clinical Endocrinology and Metabolism
Chris J MalkinT Hugh Jones

Abstract

Testosterone has immune-modulating properties, and current in vitro evidence suggests that testosterone may suppress the expression of the proinflammatory cytokines TNFalpha, IL-1beta, and IL-6 and potentiate the expression of the antiinflammatory cytokine IL-10. We report a randomized, single-blind, placebo-controlled, crossover study of testosterone replacement (Sustanon 100) vs. placebo in 27 men (age, 62 +/- 9 yr) with symptomatic androgen deficiency (total testosterone, 4.4 +/- 1.2 nmol/liter; bioavailable testosterone, 2.4 +/- 1.1 nmol/liter). Compared with placebo, testosterone induced reductions in TNFalpha (-3.1 +/- 8.3 vs. 1.3 +/- 5.2 pg/ml; P = 0.01) and IL-1beta (-0.14 +/- 0.32 vs. 0.18 +/- 0.55 pg/ml; P = 0.08) and an increase in IL-10 (0.33 +/- 1.8 vs. -1.1 +/- 3.0 pg/ml; P = 0.01); the reductions of TNFalpha and IL-1beta were positively correlated (r(S) = 0.588; P = 0.003). In addition, a significant reduction in total cholesterol was recorded with testosterone therapy (-0.25 +/- 0.4 vs. -0.004 +/- 0.4 mmol/liter; P = 0.04). In conclusion, testosterone replacement shifts the cytokine balance to a state of reduced inflammation and lowers total cholesterol. Twenty of these men had established coronary disease, and ...Continue Reading

Citations

Apr 23, 2013·Pflügers Archiv : European journal of physiology·Rayna J Gonzales
Oct 29, 2010·Pituitary·Joo Young KimEun Jig Lee
Apr 22, 2005·Reviews in Endocrine & Metabolic Disorders·S H TariqJ E Morley
May 7, 2011·Reviews in Endocrine & Metabolic Disorders·Niloufar IlaniChristina Wang
Jan 28, 2012·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Xiaofei WangBen He
Jan 29, 2011·Current Hypertension Reports·Mohadetheh MoulanaJane F Reckelhoff
Mar 20, 2012·Current Hypertension Reports·Roberta LimaJane F Reckelhoff
Nov 16, 2004·Current Urology Reports·Alvaro Morales
Sep 4, 2013·Current Urology Reports·William P Conners, Abraham Morgentaler
Apr 24, 2012·Asian Journal of Andrology·Paul D Morris, Kevin S Channer
Oct 10, 2008·International Journal of Impotence Research·M Diaz-ArjonillaC Wang
Jun 19, 2009·International Journal of Impotence Research·M Maggio, S Basaria
Oct 28, 2009·Nature Reviews. Endocrinology·Michael Zitzmann
Jun 26, 2013·Nature Reviews. Endocrinology·Preethi M RaoT Hugh Jones
May 9, 2009·Nature Reviews. Urology·Shehzad Basaria
Apr 18, 2006·International Journal of Impotence Research·M Braga-BasariaS Basaria
Sep 8, 2007·Antioxidants & Redox Signaling·Walter MalorniFlavia Franconi
Feb 1, 2013·Brain : a Journal of Neurology·Rashad HussainM Said Ghandour
Jun 27, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Marcello MaggioLuigi Ferrucci
Jan 29, 2010·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kishore M LakshmanAndre B Araujo
Mar 28, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Astrid M HorstmanMelinda Sheffield-Moore
Jul 14, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Juan Jesús CarreroPeter Stenvinkel
Sep 11, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Juan Jesús Carrero, Peter Stenvinkel
Dec 6, 2008·Current Opinion in Clinical Nutrition and Metabolic Care·William J DurhamMelinda Sheffield-Moore
May 18, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Kimberlee BurckartMelinda Sheffield-Moore
Dec 12, 2012·Current Opinion in Clinical Nutrition and Metabolic Care·Marcello MaggioGian Paolo Ceda
Nov 3, 2010·Seminars in Dialysis·Juan J Carrero, Peter Stenvinkel
Mar 9, 2007·International Journal of Clinical Practice·M M Miner, A D Seftel
Jun 16, 2012·International Journal of Clinical Practice·G Hackett
Jan 25, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Jingjing CaiYuan-Shan Zhu
Feb 4, 2012·American Journal of Physiology. Renal Physiology·Michaele B ManigrassoChristine Maric-Bilkan
Jan 1, 2011·Current Gerontology and Geriatrics Research·Mohamed A HelalyNoha El-Mashad
Apr 21, 2012·International Journal of Endocrinology·Akl C FahedSami T Azar
Nov 6, 2007·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Yan-Zhou ZhangLe-Xin Wang
Feb 16, 2011·Hypertension·Jane F Reckelhoff, Richard J Roman
Oct 1, 2010·Therapeutic Advances in Endocrinology and Metabolism·Vakkat Muraleedharan, T Hugh Jones
Oct 17, 2008·Cardiovascular Diabetology·M CarruthersA M Traish
Mar 22, 2012·Endocrinology·Sabra L Klein
Dec 4, 2008·The Journal of Clinical Endocrinology and Metabolism·Marcello MaggioLuigi Ferrucci
Feb 5, 2013·The Journal of Endocrinology·Daniel M Kelly, T Hugh Jones

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