PMID: 8603261Mar 1, 1996Paper

The effect of thalidomide on the pathogenesis of human immunodeficiency virus type 1 and M. tuberculosis infection

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association
J D KlausnerG Kaplan

Abstract

Tumor necrosis factor alpha (TNF-alpha), a cytokine produced during the host defense against infection, is associated with fevers, weakness, and progressive weight loss. Thalidomide inhibits the synthesis of TNF-alpha both in vitro and in vivo and may have clinical usefulness. We therefore initiated a pilot study of thalidomide treatment in patients with human immunodeficiency virus type 1 (HIV-1)-associated wasting with or without concomitant infection with tuberculosis. Thirty-nine patients were randomly allocated to treatment with either thalidomide or placebo in a double-blind manner for 21 days. Thirty-two patients completed the study. In patients with concomitant HIV-1 and tuberculosis infections, thalidomide therapy was associated with a reduction in both plasma TNF-alpha levels and HIV-1 levels. No significant reduction in either TNF-alpha or HIV- 1 levels was observed in patients with HIV-1 infection only. During the study period, patients receiving thalidomide treatment (n=16) showed a significant weight gain (mean +/- SEM: 6.5 +/- 1.2%; p<0.02) relative to placebo-treated patients (n=16). Patients with simultaneous HIV-1 and tuberculosis infections experienced a higher mean weight gain during thalidomide treatment th...Continue Reading

References

Mar 1, 1992·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·V Günzler
Feb 16, 1991·Lancet·L HammarströmC I Berg
Feb 16, 1991·Lancet·I WilliamsM F Waters
Mar 1, 1991·The Journal of Experimental Medicine·E P SampaioG Kaplan
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R S WallisJ J Ellner
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·G PoliA S Fauci
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·T M FolksA S Fauci
Jan 1, 1988·Advances in Immunology·B Beutler, A Cerami
Oct 1, 1994·Research in Immunology·G Kaplan, A L Moreira
Jul 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·S MakonkawkeyoonG Kaplan
Aug 1, 1993·The Journal of Infectious Diseases·E P SampaioE N Sarno

❮ Previous
Next ❯

Citations

Nov 30, 2000·Current Infectious Disease Reports·C D Hamilton
Dec 21, 2000·Current Oncology Reports·K A Nelson
Dec 6, 2001·Current Oncology Reports·Robert J Amato
Apr 20, 2001·Current Pain and Headache Reports·K A Nelson
Mar 24, 2004·Experimental Gerontology·Laurent MosoniPhilippe Patureau Mirand
Apr 27, 2000·The American Journal of Medicine·L Calabrese, A B Fleischer
Oct 26, 2002·European Journal of Pharmacology·Andrea ThieleSunna Hauschildt
Jul 4, 1998·Cancer Letters·N CarbóJ M Argilés
Jun 4, 1999·Diagnostic Microbiology and Infectious Disease·D C Macallan
Dec 3, 1998·Nutrition·H R ChangB R Bistrian
Sep 6, 2000·Clinical and Experimental Immunology·M GuckianA G Dalgleish
Jun 3, 1999·The New England Journal of Medicine·C Corcoran, S Grinspoon
May 18, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D M Aboulafia
Dec 20, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jennifer N BlanchardJane C Burns
Jun 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P HaslettG Kaplan
Feb 15, 2003·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·John E Morley
Sep 14, 2001·Current Opinion in Oncology·S E Krown
Jul 21, 1998·Journal of Pediatric Gastroenterology and Nutrition·R M JibalyS S Rabinowitz
Apr 30, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·S RiveraF R Sattler
Mar 17, 1999·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·N I PatonG E Griffin
Dec 29, 2000·Journal of Acquired Immune Deficiency Syndromes : JAIDS·D I Abrams
Dec 29, 2000·Journal of Acquired Immune Deficiency Syndromes : JAIDS·D P Kotler
Dec 1, 1999·Annals of the Rheumatic Diseases·L G Corral, G Kaplan
Apr 28, 2001·Drugs·G MantovaniC Madeddu
May 17, 2003·Clinical Therapeutics·S James Matthews, Christopher McCoy
Jul 29, 2003·Expert Opinion on Investigational Drugs·Peter D O Davies, W W Yew
Jul 17, 2008·Supportive Cancer Therapy·Aminah JatoiPhuong L Nguyen
Dec 22, 2007·Pathology, Research and Practice·Almério L L de NoronhaManoel Barral-Netto
Jan 1, 1997·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·G VanhamJ J Ellner
Apr 2, 1998·The Journal of Laboratory and Clinical Medicine·H ValdezM M Lederman
Aug 25, 2004·Trends in Immunology·Graham A W RookGeok Teng Seah
Aug 11, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R A SharmaA G Dalgleish
Sep 23, 1997·The Journal of the Association of Nurses in AIDS Care : JANAC·K M Casey
Jan 12, 2012·Journal of Chemotherapy·V Kumar, S Chhibber
Aug 18, 2005·The International Journal of Biochemistry & Cell Biology·Josep M ArgilésFrancisco J López-Soriano

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cachexia & Brown Fat

Cachexia is a condition associated with progressive weight loss due to severe illness. In cancer patients, it is proposed to occur as a result of tumor-induced energy wasting. Several proteins have been implicated in browning and depletion of white adipose tissue. Here is the latest research on cachexia and brown fat.

Cardiac Cachexia

Cardiac cachexia is a syndrome associated with the progressive loss of muscle and fat mass. It most commonly affects patients with heart failure and can significantly decrease the quality of life and survival in these patients. Here is the latest research on cardiac cachexia.