The effect of the AKT1 gene and cannabis use on cognitive performance in healthy subjects.

Journal of Psychopharmacology
M Fatjó-VilasB Arias

Abstract

Evidence suggests that the AKT1 gene may modulate the degree to which cannabis use induces cognitive alterations in patients with a psychotic disorder. To examine the interplay between AKT1 and cannabis use in terms of the cognitive performance of the general population. Our sample consisted of 389 Spanish university students. Sustained attention was measured via the Continuous Performance Test-Identical Pairs, immediate and delayed verbal memory with the Logical Memory subtest of the Wechsler Memory Scale, and working memory with the Wisconsin Card Sorting Test. Lifetime cannabis use frequency was assessed and individuals were classified as cannabis users or non-users. Two single nucleotide polymorphisms of the AKT1 gene were genotyped and, according to previous studies, each subject was defined as a carrier of two, one or no copies of the haplotype (rs2494732(C)-rs1130233(A)). Multiple linear regressions were conducted to test the effect of the genetic variability and cannabis use (and their interaction) on cognitive performance. An effect of the AKT1 haplotype was found on attention scores: individuals with two copies of the haplotype performed better (β=0.18, p<0.001 (adjusted for false discovery rate)), while neither canna...Continue Reading

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Citations

Nov 8, 2020·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Nina PocucaWilliam Perry

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Methods Mentioned

BETA
genotyping

Software Mentioned

UNPHASED
SPSS
Stata
Haploview
SDS

Related Concepts

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AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

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