The effect of the aromatase inhibitor fadrozole and two polynuclear aromatic hydrocarbons on sex steroid secretion by ovarian follicles of coho salmon

General and Comparative Endocrinology
L O AfonsoE M Donaldson

Abstract

A variety of endogenous and exogenous factors can influence sex steroid production by salmon ovarian follicles and ultimately impact reproductive development. We examined the effect of an aromatase inhibitor, fadrozole, and common environmental contaminants (PAHs) on sex steroid secretion by ovarian follicles. Ovarian follicles of coho salmon were incubated in vitro with various concentrations of testosterone (0.10-0.40 microM) and fadrozole (10 and 100 microM), or with varying doses (between 0.05 and 5.0 microM) of the PAHs beta-naphthoflavone (BNF) and 20-methylcholanthrene (20-MC). 17 beta-Estradiol secretion was significantly reduced when follicles were incubated in the presence of fadrozole, BNF, or 20-MC. In contrast, 17 beta-estradiol production by ovarian follicles increased in a dose-dependent manner when incubated with increasing doses of the aromatizable androgen testosterone. Although increasing doses of PAHs significantly reduced follicular 17 beta-estradiol production no effect on testosterone secretion was observed. Hence, both fadrozole and PAHs can significantly reduce 17 beta-estradiol secretion by salmon ovarian follicles and may affect female sexual development.

References

Dec 1, 1992·Biology of Reproduction·P M CampbellJ P Sumpter
Jan 24, 1992·Science·A Elbrecht, R G Smith
Mar 1, 1990·General and Comparative Endocrinology·J F Carragher, J P Sumpter
Apr 1, 1994·General and Comparative Endocrinology·J WadeA P Arnold
Sep 1, 1995·General and Comparative Endocrinology·K L Wennstrom, D Crews
Feb 1, 1995·Fish Physiology and Biochemistry·E AntonopoulouB Borg
Jul 1, 1993·Fish Physiology and Biochemistry·Y NagahamaM Tanaka

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Citations

Jul 12, 2005·Proceedings. Biological Sciences·Frederieke J KroonN Robin Liley
Mar 3, 2010·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Sabina RuksanaMasaru Nakamura
Jan 24, 2015·Zygote : the Biology of Gametes and Early Embryos·Wei-Wei XueJiang-Dong Liu
Jul 28, 2006·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Peter S LeeHenry R King
Jun 30, 2006·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Toru KomatsuMasaru Nakamura
May 13, 2015·General and Comparative Endocrinology·Christopher J Kennedy, Kevin R Smyth
Mar 9, 2004·Aquatic Toxicology·Martina Fenske, Helmut Segner
Jul 20, 2001·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·S ChatterjeeR Ghosh
Jun 19, 2001·Molecular and Cellular Endocrinology·G Séralini, S Moslemi
Nov 28, 2012·Environmental Science & Technology·K J Ralston-HooperP L Ferguson

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