The Effect of the Bariatric Surgery Type on the Levothyroxine Dose of Morbidly Obese Hypothyroid Patients

Obesity Surgery
Jorge PedroDavide Carvalho

Abstract

Doubts exist about the effect of different bariatric surgery (BS) types on levothyroxine (Lt4) absorption. We compared Lt4 doses and their variation (ΔLt4) in patients with hypothyroidism that underwent malabsorptive (MS) or restrictive (RS) surgery and studied predictors of Lt4 dose change. Retrospective study of morbidly obese hypothyroid patients submitted to BS. We compared RS ("sleeve" gastrectomy or adjustable gastric banding) with MS (Roux-en-Y gastric bypass) patients. We built a multivariable logistic regression and a linear regression model to study predictors of Lt4 dose changes and ΔLt4, respectively. Fifty-seven patients: 35 MS and 22 RS. Mean age 47 years; 7% men. Patients submitted to MS had lower BMI at 1 year than those submitted to RS. Lt4 dose remained unchanged in 61.4%, increased in 12.3%, and decreased in 26.3% of patients. Initial and 1-year Lt4 dose were not different between surgical groups. Relative Lt4 dose, but not absolute (p = 0.07), increased at 1 year (p < 0.001). Neither BS nor BMI variation were predictors of Lt4 dose variation. BMI variation was associated with relative Lt4 dose change independently of initial BMI and BS type: β (95%CI) - 0.03 (- 0.05; 0.00); p = 0.03. There were no difference...Continue Reading

References

Jun 1, 1979·Annals of Internal Medicine·F AziziJ Albano
Jan 1, 1976·Clinical Pharmacokinetics·W S Nimmo
May 8, 2004·Obesity Surgery·Yannis RaftopoulosPhilip F Caushaj
Oct 16, 2004·The Journal of Clinical Endocrinology and Metabolism·Ferruccio SantiniPaolo Vitti
Nov 27, 2009·Postgraduate Medicine·Xavier Pi-Sunyer
Nov 28, 2009·Best Practice & Research. Clinical Endocrinology & Metabolism·Llanyee Liwanpo, Jerome M Hershman
Apr 21, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C LubranoG Spera
Jul 14, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C N OchnerA Geliebter
Mar 23, 2011·Thyroid : Official Journal of the American Thyroid Association·Marina A MichalakiKostas B Markou
Jun 3, 2011·Obesity Surgery·Ileana Gabriela Sanchez RubioGeraldo Medeiros-Neto
Oct 27, 2011·Journal of Diabetes Science and Technology·Viorica Ionut, Richard N Bergman
Nov 19, 2011·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·April SmithAndrew Cohen
Jul 4, 2012·Current Drug Metabolism·Ronald Andari SawayaFrank K Friedenberg
Sep 8, 2012·Thyroid : Official Journal of the American Thyroid Association·Jeffrey R GarberUNKNOWN American Association Of Clinical Endocrinologists And American Thyroid Association Taskforce On Hypothyroidism In Adults
Nov 1, 2012·Thyroid : Official Journal of the American Thyroid Association·Margarita GkotsinaKostas B Markou
Dec 19, 2012·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Jeffrey R GarberUNKNOWN American Association of Clinical Endocrinologists and American Thyroid Association Taskforce on Hypothyroidism in Adults
Jan 16, 2013·Journal of the American College of Surgeons·Kristin A OjomoRebecca S Sippel
Feb 5, 2013·Seminars in Nephrology·Hermann J Kissler, Utz Settmacher
Jul 10, 2013·Nature Reviews. Gastroenterology & Hepatology·Alexander D Miras, Carel W le Roux
Dec 24, 2013·Diabetes & Metabolism·I QuerciaB Laferrère
Feb 21, 2016·Thyroid : Official Journal of the American Thyroid Association·Paola FierabracciFerruccio Santini
Aug 1, 2016·Obesity Surgery·Silpa GadirajuDavid S Cooper
Feb 6, 2017·Clinical Therapeutics·Marko SkelinDario Rahelić
Jan 8, 2018·The American Journal of Emergency Medicine·Maria S AltieriAurora D Pryor

❮ Previous
Next ❯

Citations

Aug 12, 2019·BMJ Case Reports·Laurent BrutusClément Le Glatin
Feb 16, 2021·Frontiers in Endocrinology·Camilla ViriliMarco Centanni
Apr 12, 2021·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Carmil AzranIlan Matok
Dec 3, 2021·Obesity Surgery·Jan Peter YskaEric N van Roon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved