Abstract
The effect on cognitive and psychomotor performance of the benzodiazepine (BZD) antagonist, flumazenil, in antagonising the central effect, of ethanol in man has been investigated. Eight healthy adult male volunteers, aged 23 to 32 years, participated in the study. Following a loading infusion, stable blood ethanol levels with a mean value of 1.6 g x l-1 were produced by a maintenance infusion. When stable blood levels of ethanol were reached, 5.0 mg flumazenil/placebo was administered intravenously, and after 15 and 75 min a test battery evaluating psychomotor and cognitive functions was applied. The test battery was sensitive to the test model, but no significant improvement in the test scores could be demonstrated following the administration of flumazenil. It is concluded that flumazenil has no influence on psychomotor functions in acute ethanol intoxication.
References
Jan 1, 1979·Journal of Neural Transmission·S Liljequist, J Engel
Dec 17, 1976·Naunyn-Schmiedeberg's Archives of Pharmacology·J CottM Lindqvist
Feb 1, 1985·Anesthesia and Analgesia·P N Van GorderJ M Cook
Jul 1, 1985·Anesthesiology·P M LauvenD J Greenblatt
Sep 1, 1987·Clinical Pharmacology and Therapeutics·G F O'Sullivan, D N Wade
Jan 1, 1986·Psychopharmacology·S E File, S Pellow
Dec 5, 1986·Science·P D SuzdakS M Paul
Jan 1, 1986·Psychopharmacology·A HiggittP Fonagy
Oct 1, 1986·Anaesthesia·J WolffB O Mikkelsen
Nov 1, 1986·British Journal of Clinical Pharmacology·U KlotzG Mikus
Jan 1, 1985·Psychopharmacology·R Radlow, P M Hurst
Jan 1, 1985·European Neurology·G Scollo-Lavizzari, H Matthis
May 1, 1983·British Journal of Clinical Pharmacology·J M Gaillard, R Blois
Oct 1, 1984·Pharmacology, Biochemistry, and Behavior·S Liljequist, J A Engel
Feb 1, 1980·Journal of Neurochemistry·M K Ticku, T Burch
Apr 9, 1981·Nature·W HunkelerW Haefely
May 6, 1981·Neuroscience Letters·W C Davis, M K Ticku
Apr 1, 1984·Journal of Neurochemistry·D A GreenbergI Diamond
May 1, 1984·Pharmacopsychiatry·J SchöpfJ M Gaillard
Nov 1, 1982·British Journal of Clinical Pharmacology·A DarraghC O'Boyle
Jan 1, 1981·Pharmacology·J S DavisS S Parmar
Citations
Jul 1, 1991·Pharmacology, Biochemistry, and Behavior·A W ChanF Penetrante
Feb 15, 2001·Brain Research·W B Mendelson
Oct 1, 1992·British Journal of Clinical Pharmacology·G W KunsmanM A Przekop
Mar 1, 1993·Human & Experimental Toxicology·P LheureuxR Askenasi