PMID: 1281596Jan 1, 1992

The effect of the bronchoalveolar fluid of mice infected with the influenza virus on hematopoietic bone marrow precursors

Zhurnal mikrobiologii, epidemiologii, i immunobiologii
V F LavrovO N Ageeva


The influence of bronchoalveolar washing fluid (BAWF), as well as BAWF cells, obtained from mice infected with influenza virus, on the formation of exogenic spleen colony-forming units (CFUs) of lethally irradiated syngeneic recipients was studied. BAWF and BAWF cells of intact syngeneic mice stimulated the growth of CFUs. BAWF of mice infected with nonpathogenic strain A/PR/8/34 lost its capacity for stimulating the growth of colonies, and BAWF cells greatly suppressed colony formation in the spleen of recipients. The participation of interferon, colony-stimulating factor and the virus itself in the process of the modulation of colony formation is discussed.

Related Concepts

Bone Marrow Cells
Bronchoalveolar Lavage Fluid
Colony-Forming Units Assay
Colony-Forming Units, Hematopoietic
Mice, Inbred CBA
Mice, Inbred C57BL
Orthomyxoviridae Infections
Orthomyxovirus Type A, Porcine

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