The Effect of the Canine ABCB1-1Δ Mutation on Sedation after Intravenous Administration of Acepromazine

Journal of Veterinary Internal Medicine
D DeshpandeM A Gieseg

Abstract

Dog breeds with the ABCB1-1Δ mutation have substantially truncated nonfunctional P-glycoprotein. Dogs homozygous for this mutation (mut/mut) are susceptible to the toxic adverse effects of ivermectin, loperamide, and vincristine. Anecdotal reports suggested ABCB1 mut/mut dogs showed increased depth and duration of acepromazine sedation. That ABCB1 mut/mut dogs have increased depth and duration of sedation after acepromazine IV compared to normal dogs (nor/nor). Twenty-nine rough-coated collies were divided into 3 groups of dogs based on their ABCB1 genotype: 10 mut/mut, 10 mut/nor, and 9 nor/nor. Dogs were given 0.04 mg/kg of acepromazine IV. Level of sedation, heart rate, respiratory rate, and blood pressure were recorded for 6 hours after acepromazine administration. Area under the curves (AUCs) of the normalized sedation score results were calculated and compared. The median sedation scores for ABCB1 mut/mut dogs were higher than nor/nor dogs at all time points and were higher in mut/nor dogs for the first 2 hours. These differences were not found to be significant for any individual time point (P > .05). The median sedation score AUC for mut/mut dogs was significantly higher than nor/nor dogs (P = .028), but the AUC for mut...Continue Reading

References

Feb 1, 2003·European Journal of Pharmacology·Alain RouletThierry Pineau
Nov 25, 2003·Journal of the American Veterinary Medical Association·Katrina L MealeySteven A Bentjen
Feb 10, 2004·Journal of Veterinary Internal Medicine·Laura L SartorKatrina L Mealey
Aug 4, 2004·Proceedings of the National Academy of Sciences of the United States of America·Mark W NeffNiels C Pedersen
Apr 14, 2005·Journal of the American Veterinary Medical Association·Erik H Hofmeister, Christine M Egger
Apr 6, 2006·Journal of Veterinary Internal Medicine·Rosemary A HenikKatrina L Mealey
Feb 9, 2007·The Journal of Small Animal Practice·E H HofmeisterS C Budsberg
Mar 12, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Katrina L MealeyFrederick Nelson
Jun 10, 2008·Journal of Veterinary Internal Medicine·K L MealeyP J Bergman
Jul 22, 2008·Journal of Veterinary Pharmacology and Therapeutics·M MartinezK Mealey
Oct 17, 2008·Veterinary Parasitology·Katrina L Mealey
Nov 16, 2010·Journal of the American Veterinary Medical Association·Erik H HofmeisterMatt R Read
Nov 30, 2011·The Journal of Small Animal Practice·L KrugmanA Chen
Apr 18, 2014·Journal of the American Veterinary Medical Association·Michelle A Giuffrida

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Citations

Jun 20, 2018·Journal of Veterinary Pharmacology and Therapeutics·Marilyn N MartinezKatrina L Mealey
Nov 20, 2019·Australian Veterinary Journal·R W SoussaC M Cannon
Sep 12, 2017·Journal of Veterinary Pharmacology and Therapeutics·K Kongara
Mar 12, 2019·Frontiers in Veterinary Science·Deirdre P Campion, Fiona J Dowell
Jul 6, 2021·Journal of Veterinary Pharmacology and Therapeutics·Mark C HeitStephen B King

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Methods Mentioned

BETA
sedation
genotyping

Software Mentioned

R Core Team
R

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