The effect of the corticosteroid hormone cortexolone on the metabolites produced during phenanthrene biotransformation in Cunninghamella elegans

Chemosphere
Katarzyna LisowskaC E Cerniglia

Abstract

The metabolism of phenanthrene and the mammalian corticosteroid hormone cortexolone by the fungus Cunninghamella elegans was studied. The amounts of the cortexolone transformation products, cortisol and epicortisol, were affected by the presence of phenanthrene. Approximately 40% more cortisol was produced by C. elegans in cultures with phenanthrene. In contrast, epicortisol formation decreased. C. elegans transformed phenanthrene to phenanthrene trans-1,2-,3,4-, and 9,10-dihydrodiols, phenols, diphenols (diols) and glucoside conjugates of 1-, 2-, 3-, 4-, and 9-phenanthrols. Almost all of the phenanthrene initially added was metabolized to ethyl acetate extractable metabolites. In the mycelia and culture medium extracts, phenanthrol glucosides represented 80% and 94% of the total metabolites, respectively. The major metabolite was the glucoside conjugate of 1-phenanthrol. The presence of cortexolone affected the biodegradation of phenanthrene by decreasing the amounts of phenanthrene metabolites compared to control cultures.

References

Jan 1, 1992·Journal of Industrial Microbiology·J B Sutherland
Jan 1, 1990·Archives of Microbiology·J B SutherlandC E Cerniglia
Apr 1, 1997·Steroids·S B Mahato, S Garai
Feb 19, 2000·Biochemical and Biophysical Research Communications·J S Yadav, J C Loper
May 31, 2003·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Berrin SerdarStephen M Rappaport
Dec 14, 2004·Applied Microbiology and Biotechnology·Yong-Hak KimCarl E Cerniglia

❮ Previous
Next ❯

Citations

Jun 26, 2007·Acta Pharmacologica Sinica·Bin MaDa-fang Zhong
Mar 23, 2013·Marine Environmental Research·Carla B SetteAngela de L R Wagener
Sep 1, 2010·Mycobiology·Xin Yu WangJae-Seoun Hur
Feb 9, 2010·Environmental Science & Technology·Stine N SchmidtAnders R Johnsen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bioremediation (ASM)

Bioremediation is the treatment and removal of harmful pollutants or contaminants through the use of microorganisms. Discover the latest research here.