PMID: 8471966Jan 1, 1993Paper

The effect of the drug-induced activation and deprivation of the sympathetic nervous system on aldosterone receptor binding by the kidney with disturbed neurotrophic support

Izvestiia Akademii nauk. Seriia biologicheskaia
Iu A AkimovA A Rodionov

Abstract

The results of studies are presented on the determination of aldosterone accumulation by mineralocorticoid receptors on cytoplasm and nuclei of normal rat renal tubules as well as in disturbed neurotrophic supply of the kidney including that against the background of activation and deprivation of the sympathetic nervous system function. It was shown that a pharmacological stimulation of sympathetic nervous system potentiated functional disturbances of the renal mineralocorticoid receptor apparatus in reflex dystrophy of the kidney. A simultaneous pharmacological blockade both of neural and of humoral transmission of pathological stimuli from damaged sciatic nerve to the kidney prevented the development of these disturbances. A belief is stated that there is a possibility of using adrenoceptor blockers as means to prevent or inhibit the development of dystrophic alterations in the organism which appear under the lesion of one or other part of the nervous system.

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.