The effect of the gastrectomy on survival in patients with metastatic gastric cancer: a study of ASMO

Future Oncology
Ozan YazıcıNurullah Zengin

Abstract

To investigate the role of surgical resection of primary tumor on overall survival (OS) in advanced gastric cancer patients at the time of diagnosis. The survival rates of metastatic gastric cancer patients whose gastric primary tumor was resected at time of diagnosis were compared with metastatic gastric cancer patients whose primary tumor was nonresected. The median progression-free survival and OS in operated and nonoperated group were 10 versus 6, 14 versus 9 months, respectively (p < 0.001). In multivariate analysis, gastric resection of primary tumor, Eastern Cooperative Oncology Group performance status, second-line chemotherapy had a significant effect on OS (hazard ratio [HR]: 0.52 [95% CI: 0.38-0.71], HR: 0.57 [95% CI: 0.42-0.78], HR: 1.48 [1.09-2.01]; p ≤ 0.001, p = 0.001 and p = 0.012, respectively). Subpopulations of patients with metastatic gastric cancer might benefit from surgical removal of primary tumor.

References

Jul 15, 1988·Cancer·M T HallisseyJ W Fielding
May 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D M FinkelsteinJ C Ruckdeschel
Sep 1, 1994·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M FindlayH Ford
Oct 23, 2002·The British Journal of Surgery·H H HartgrinkUNKNOWN Dutch Gastric Cancer Group
Nov 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eric Van CutsemUNKNOWN V325 Study Group
Jul 6, 2007·Journal of Cancer Research and Clinical Oncology·Sheng-Zhang LinJun-Liang Zhou
Aug 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jaffer A AjaniUNKNOWN V-325 Study Group
Jul 23, 2008·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A BajwaA O'Bichere
Aug 2, 2008·Current Opinion in Urology·Vitaly MargulisChristopher G Wood
Jul 22, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Ahmedin JemalElizabeth M Ward
May 24, 2011·American Journal of Surgery·Jian-Zhong ZhangXian-Fu Zhang
Aug 23, 2011·The British Journal of Surgery·N Bhoo PathyC H Yip
Nov 3, 2011·Annals of Surgical Oncology·Ye Rim ChangHan-Kwang Yang
Dec 15, 2011·Polski przeglad chirurgiczny·Tariq Al-AmawiJózef Kładny
Mar 3, 2012·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·P KuligJ Kulig
Mar 13, 2012·World Journal of Gastroenterology : WJG·Anna Maria ChiaravalliEnrico Solcia
Jun 1, 2012·Journal of Surgical Oncology·Shi ChenYing-Bo Chen

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Methods Mentioned

BETA
surgical resection

Software Mentioned

SPSS

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