PMID: 3558029Mar 1, 1987

The effect of the hydrolytic state of dietary protein on post-irradiation morbidity and mucosal cell regeneration

International Journal of Radiation Oncology, Biology, Physics
M K BeitlerM L Hutchinson

Abstract

Diets containing hydrolyzed casein have been observed to enhance post-irradiation intestinal mucosal recovery. The intake and the composition of such diets were not carefully controlled. This study attempted to do so. Male specific pathogen-free Sprague-Dawley rats were randomized to receive either an enzymatically hydrolyzed casein semi-purified diet (EHC), a whole casein semi-purified diet (WC), or powdered lab chow (C). All diets were isonitrogenous, and the WC and C rats were pair-fed to the ad libitum fed EHC rats. Seven days after initiation of feeding, the rats were abdominally irradiated with a single 9.0 Gy dose of 137Cs gamma rays. The rats were continued on the diets for another 5 days. Intestinal mucosa from transverse segments at the duodenum, jejunum, proximal ileum, and distal ileum were measured for incorporation of (3H methyl) Thymidine 1 hour after interperitoneal injection. Incorporation reached a maximum by day 4 post-irradiation regardless of diet or segment. Incorporation in the duodenum was enhanced by the EHC diet compared to the C diet, while the incorporation in the jejunum was initially suppressed by the EHC diet compared to the WC diet. In the jejunum, the number of mitoses per crypt of 25 anti-mesen...Continue Reading

Citations

Oct 1, 1991·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Y SarriR Gomis

Related Concepts

Trypticase
Casein A
Structure of Intestinal Gland
Protein Hydrolysates
Radiation Injuries, Experimental
Natural Regeneration

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