The effect of the levonorgestrel-releasing intrauterine system and the copper intrauterine device on subendometrial microvascularization and uterine artery blood flow

Fertility and Sterility
Mirela F JiménezJoão S L Cunha-Filho

Abstract

To evaluate the effect of the levonorgestrel intrauterine system (LNG-IUS) and TCU 380A on the subendometrial vascularization and the uterine artery blood flow during the midluteal phase. Prospective clinical trial. Teaching hospital. The trial included 27 patients who received the LNG-IUS compared with 25 patients who received the TCU 380A. The subendometrial blood flow was evaluated using power Doppler analysis, uterine artery pulsatility index (PI), and resistance index (RI) just before inserting the intrauterine device in the midluteal phase and 3 months after. Power Doppler analysis, PI, RI, and endometrial thickness. There were no significant differences in subendometrial vascularization between the groups. Pulsatility index and RI variability (before and after) increased and endometrial thickness reduced in LNG-IUS users. We used the multiple logistic regression model to examine the potential confounding bias (age and parity). The LNG-IUS was independently associated with increased PI. No subendometrial microvascularization difference was found between the groups. It is the first direct evidence that LNG-IUS reduced uterine artery blood flow, even after controlling for age and parity.

References

Feb 1, 1996·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·J ZaidiS L Tan
May 1, 1994·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M MomtazO Idriss
Sep 20, 2005·Reproductive Biomedicine Online·M F JiménezJ S L Cunha-Filho
Feb 2, 2006·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·A HaberalO Ozdegirmenci

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Citations

Jun 29, 2010·Archives of Gynecology and Obstetrics·Mostafa Hussein
Jul 1, 2009·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Banu DaneAhmet Cetin
Aug 16, 2011·Placenta·S L CollinsL Impey
Oct 1, 2008·Journal de gynécologie, obstétrique et biologie de la reproduction·P MadelenatUNKNOWN Groupe de réflexion sur la contraception progestative
Jun 24, 2020·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Hanifi ŞahinRahime Nida Bayik
Aug 8, 2021·Human Reproduction·Jungho AhnYoun-Jung Kang

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