The effect of the mTOR inhibitor rapamycin on glucoCEST signal in a preclinical model of glioblastoma

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Xiang XuKannie Chan

Abstract

The mammalian target of rapamycin is an enzyme that regulates cell metabolism and proliferation. It is up-regulated in aggressive tumors, such as glioblastoma, leading to increased glucose uptake and consumption. It has been suggested that glucose CEST signals reflect the delivery and tumor uptake of glucose. The inhibitor rapamycin (sirolimus) has been applied as a glucose deprivation treatment; thus, glucose CEST MRI could potentially be useful for monitoring the tumor responses to inhibitor treatment. A human U87-EGFRvIII xenograft model in mice was studied. The mice were treated with a mammalian target of Rapamycin inhibitor, rapamycin. The effect of the treatment was evaluated in vivo with dynamic glucose CEST MRI. Rapamycin treatment led to significant increases (P < 0.001) in dynamic glucose-enhanced signal in both the tumor and contralateral brain as compared to the no-treatment group, namely a maximum enhancement of 3.7% ± 2.3% (tumor, treatment) versus 1.9% ± 0.4% (tumor, no-treatment), 1.7% ± 1.1% (contralateral, treatment), and 1.0% ± 0.4% (contralateral, no treatment). Dynamic glucose-enhanced contrast remained consistently higher in treatment versus no-treatment groups for the duration of the experiment (17 min). ...Continue Reading

References

Oct 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·D L RothmanR G Shulman
Feb 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·R GruetterW V Tamborlane
Feb 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P S Tofts, A G Kermode
Jun 1, 1986·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J C GoreI M Armitage
Oct 15, 1984·The Biochemical Journal·M H GiroixW J Malaisse
Nov 1, 1994·Brain Research. Molecular Brain Research·R J BoadoW M Pardridge
Nov 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P C van ZijlP van Gelderen
Dec 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K M DonahueB R Rosen
Jan 1, 1997·Journal of Magnetic Resonance Imaging : JMRI·P S Tofts
Nov 1, 2001·Topics in Magnetic Resonance Imaging : TMRI·M V KnoppP Choyke
Jul 3, 2002·Nature Reviews. Cancer·Igor Vivanco, Charles L Sawyers
Jul 20, 2002·Biological Research·Rodolfo A Medina, Gareth I Owen
Sep 25, 2004·Journal of Cellular Physiology·Maria L MachedaJames D Best
Nov 2, 2004·Nature Reviews. Cancer·Robert A Gatenby, Robert J Gillies
Jul 7, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Evanthia GalanisUNKNOWN North Central Cancer Treatment Group
Feb 1, 2007·Journal of Neuroscience Research·Luc LeybaertElke De Vuyst
Feb 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·Wen LingAlexej Jerschow
Feb 19, 2008·Cancer Research·Panomwat AmornphimolthamJ Silvio Gutkind
Jun 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Liu Hua WeiWolfgang A Weber
Oct 16, 2009·Current Medical Imaging Reviews·Thomas E Yankeelov, John C Gore
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
May 25, 2012·The British Journal of Radiology·J P B O'ConnorA Jackson
Oct 18, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kannie W Y ChanPeter C M van Zijl
Dec 25, 2012·Brain Research·Antonietta ArcellaFrancesco Fornai
May 16, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Fatima A NasrallahKai-Hsiang Chuang
Jul 9, 2013·Nature Medicine·Simon Walker-SamuelXavier Golay
Feb 11, 2014·Cell Metabolism·Jing LiJohn Blenis
May 29, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Tao JinSeong-Gi Kim
Jun 17, 2014·Clinical Oncology : a Journal of the Royal College of Radiologists·Q Q TeoQ S Ng
Jun 25, 2014·Magnetic Resonance Imaging·Zhongliang ZuJohn C Gore
Jul 1, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Nirbhay N YadavPeter C M van Zijl
Sep 6, 2015·Gene·Zekeriya DuzgunCigir Biray Avci
Sep 26, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Xiang XuPeter C M van Zijl
Jan 16, 2016·Cell Metabolism·Natalya N Pavlova, Craig B Thompson
Jan 19, 2016·Tomography : a Journal for Imaging Research·Xiang XuPeter C M van Zijl
Feb 24, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jiadi XuPeter C M van Zijl
May 5, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wolfgang WickMonika E Hegi
May 11, 2016·Journal of Cancer·Slobodan Devic
Jun 14, 2016·Brain Tumor Pathology·Kenta MasuiPaul S Mischel
Nov 5, 2016·Expert Opinion on Emerging Drugs·Julie J Miller, Patrick Y Wen
Feb 9, 2017·Scientific Reports·Patrick SchuenkeMoritz Zaiss

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Citations

Aug 2, 2019·Scientific Reports·Puneet BaggaRavinder Reddy
Feb 4, 2021·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Qi QiJonathan D Thiessen
Aug 13, 2021·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Martina CapozzaSilvio Aime
Nov 16, 2021·NMR in Biomedicine·Zheng HanGuanshu Liu

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