The effect of the new triazole, voriconazole (UK-109,496), on the interactions of Candida albicans and Candida krusei with endothelial cells

Journal of Chemotherapy
R A FrattiM Ghannoum

Abstract

In this study, we investigated how voriconazole affects specific endothelial cell interactions utilizing both fluconazole-susceptibles and resistantR Candida albicans strains (C. albicansS and C. albicansR, respectively) as well as Candida krusei. Our data show that exposing C. albicansS to voriconazole significantly reduced its adherence to endothelial cells (p <0.001). The adherence of C. albicansR to endothelial cells was not affected by treatment with either antifungal agent. Exposure of C. albicans to both agents inhibited germ tube formation; however, voriconazole showed higher ability in inhibiting germination as compared with fluconazole. The effect of antifungals on germination was also tested during co-incubation of yeast cells with endothelial cells. Pretreated C. albicansS cells germinated on endothelial cells in the presence of voriconazole or fluconazole. However, the degree of germination was reduced by 81% and 16%, respectively. Similar results were observed with C. albicansR. Our data demonstrate that voriconazole treatment reduced the median germ tube length of C. albicansS and C. albicansR by approximately 60%, whereas fluconazole reduced the germ tube length of these strains by 27% and 63%, respectively (P <...Continue Reading

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Citations

Jan 14, 2009·Cases Journal·Fernanda C CabralClaudia M Mano
Feb 20, 2016·Journal of the American Podiatric Medical Association·Mahmoud Ghannoum
Apr 2, 2002·The Journal of Investigative Dermatology. Symposium Proceedings·M A Ghannoum
Oct 27, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Nov 18, 2003·British Journal of Clinical Pharmacology·Atholl Johnston
Mar 28, 2006·International Journal of Antimicrobial Agents·Dominique LevêqueRaoul Herbrecht
Jan 31, 2006·International Journal of Pharmaceutics·Moustafa M G FoudaEckhard Schollmeyer
Jul 13, 2001·Infectious Disease Clinics of North America·H L Leather, J R Wingard
Mar 5, 2004·International Journal of Clinical Practice·P Gothard, T R Rogers
Sep 12, 2000·The Annals of Pharmacotherapy·J A Sabo, S M Abdel-Rahman

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