PMID: 6238099Jan 1, 1984Paper

The effect of the non-steroidal anti-inflammatory drug Etodolac on macrophage migration in vitro and in vivo

Journal of Immunopharmacology
F GervaisE Skamene

Abstract

The possible mode of action of Etodolac, a potent anti-inflammatory drug, has been investigated. The effect of Etodolac on macrophage inflammatory depressed the influx of inflammatory macrophages into peritoneal cavity following stimulation with a sterile irritant. This decrease in macrophage accumulation in vivo correlated with the effect of Etodolac on the macrophage chemotaxis in vitro. Etodolac was also capable of reducing the macrophage ability to migrate towards a chemoattractant. In vivo Etodolac should reduce the amount of damage produced at the site of chronic inflammation since fewer macrophages would migrate to the inflammatory sites.

Citations

Jan 1, 1990·Agents and Actions·M K ThomsenI Ahnfelt-Rønne
Sep 6, 2005·Journal of the American Animal Hospital Association·Stephen L CurryJames L Cook
Oct 30, 2007·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Hizuru MiyamotoHideaki Sakashita
Jul 6, 2007·Journal of Ethnopharmacology·William Chi Shing Cho, Kwok Nam Leung
Jan 16, 2007·Cancer Letters·William C S Cho, Kwok N Leung

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