PMID: 7018894Aug 1, 1980Paper

The effect of the oxidizing agents chloramine-T and cigarette smoke on dog serum proteinase inhibitor(s)

Experimental Lung Research
W R AbramsG Weinbaum

Abstract

Dog serum treated with the oxidant chloramine-T is rapidly and selectively depleted of its ability to inhibit porcine pancreatic elastase or dog neutrophil elastase. Trypsin inhibitory capacity of serum is not affected. Purified dog alpha-1-proteinase inhibitor (alpha-1-PI) is similarly oxidized with an apparent rate constant of 1.1 x 10(3) M-1 sec-1. Reversal of the oxidative inactivation using dithiothreitol was demonstrated. Cigarette smoke also directly affects the inhibitory capacity of both serum and pure alpha-1-PI. These studies form a basis for developing a model of functionally deficient alpha-1-PI by taking advantage of oxidative inactivation of normal proteinase inhibitor levels.

References

Sep 1, 1977·The Journal of Experimental Medicine·R WhiteC Kuhn
Apr 2, 1979·Clinica Chimica Acta; International Journal of Clinical Chemistry·D VercaigneJ P Raoult
Aug 22, 1978·Biochemistry·W R AbramsG Weinbaum
Aug 1, 1975·The Journal of Experimental Medicine·Z Werb, S Gordon
May 28, 1979·Biochemical and Biophysical Research Communications·N R MathesonJ Travis
Jan 15, 1979·Biochemical and Biophysical Research Communications·S SatohM Laskowski
Oct 7, 1975·Biochemistry·Y ShechterA Patchornik
Nov 1, 1961·Archives of Biochemistry and Biophysics·B F ERLANGERW COHEN
Mar 20, 1937·The Journal of General Physiology·M L Anson

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Citations

Jun 1, 1996·Inflammation·M E HanleyJ E Repine
Nov 1, 1991·Biological Trace Element Research·M A Dubick, C L Keen
Jan 1, 1995·Free Radical Biology & Medicine·W Vogt
Jan 22, 1981·The New England Journal of Medicine·C T LeeG Weinbaum
Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·W R AbramsN Brot
Jan 1, 1988·Experimental Lung Research·W R AbramsG Weinbaum
Jun 1, 1989·Scandinavian Journal of Clinical and Laboratory Investigation·H SchulzM Meyer
May 1, 1983·Archives of Biochemistry and Biophysics·N Brot, H Weissbach
Dec 1, 1983·Hoppe-Seyler's Zeitschrift für physiologische Chemie·G J AlbrechtJ P Salier

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