The effect of the paraoxonase 1 (PON1) T(-107)C polymorphism on serum PON1 activity in women is dependent on fatty acid intake

Nutrition Research
Fabiola G SantosAugusto Schneider

Abstract

Paraoxonase 1 (PON1) is an enzyme that prevents the peroxidation of lipoprotein and cell membranes. Our hypothesis is that the effect of the PON1 T(-107)C polymorphism on serum PON1 activity in healthy adult women is dependent on their fatty acid intake profile. This study included women (n = 39) who completed a food frequency questionnaire. Fatty acid intake was estimated based on the interview and a nutrient reference table. Blood samples were collected for genotyping and to measure serum PON1 activity. Serum PON1 activity was different among genotypes and was higher for women of the CC genotype (P < .001). Women in the study were categorized in 2 groups according to the median nutrient intake. Overall, there was a difference (P < .05) in serum PON1 activity between the CC and TT genotypes in women ingesting either above or below the median total fat, saturated fatty acids, monounsaturated fatty acids, polyunsaturated fatty acids, omega 3 (n-3) and omega 6 (n-6; P < .05). However, genotype effects on serum PON1 activity were not observed in women ingesting below the median (15:1) ratio of n-6/n-3 (P > .05) but were observed in women ingesting above the ratio of n-6/n-3 (P < .05). This is partly because women of the CC genotyp...Continue Reading

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Citations

Jul 12, 2017·Reproduction in Domestic Animals = Zuchthygiene·J PradieéA Schneider
Sep 3, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Patrícia Britto CostaCarlos Castilho Barros
May 1, 2019·Archives of Endocrinology and Metabolism·Mauren Castro RittaAugusto Schneider
Dec 5, 2018·Theriogenology·Pedro Augusto Silva SilveiraAugusto Schneider
Apr 13, 2021·Archives of Endocrinology and Metabolism·Aline LongoRenata Torres Abib Bertacco
Nov 12, 2021·Archives of Endocrinology and Metabolism·Bianka Machado ZaniniAugusto Schneider

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