PMID: 70261Oct 7, 1977Paper

The effect of the retrograde axonal transport of nerve growth factor on the morphology of adrenergic neurones

Brain Research
I A Hendry

Abstract

An injection of nerve growth factor (NGF) into one eye of neonatal rats results in an increase in the tyrosine hydroxylase activity of the ipsilateral superior cervical ganglion. This effect was seen maximally after the intraocular injection of a depot preparation of NGF linked to cellulose. The sympathetic neurones that innervate the eye can be identified by autoradiography after the retrograde axonal transport of either NGF or tetanus toxin labelled with [125I]iodine. It was only those cells having their terminals in the vicinity of the depot preparation. This demonstrates that NGF transported from the periphery to the cell bodies is effectively retained within the transporting cell and is not released to act on extracellular receptors within the ganglion. It is suggested that this specificity of action for NGF reaching the ganglion in this fashion is important during normal development in determining the survival of adrenergic neurones.

References

Oct 1, 1975·The Journal of Cell Biology·K Herrup, E M Shooter
Mar 15, 1974·Brain Research·I A HendryL L Iversen
Aug 23, 1974·Brain Research·K StöckelH Thoenen
Sep 1, 1974·The Journal of Physiology·L Landmesser, G Pilar
Sep 1, 1974·The Journal of Physiology·L Landmesser, G Pilar
May 1, 1974·British Medical Bulletin·M C Prestige
Sep 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·S P BanerjeeL A Greene
Oct 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·W A FrazierR A Bradshaw
Apr 1, 1973·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·E HoltzmanE R Peterson
Jun 30, 1972·Science·J H LaVail, M M LaVail

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Citations

Dec 1, 1992·Pharmacology & Therapeutics·I A Hendry
Feb 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·S NasiP Calissano
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S C FeinsteinP Coffino
Feb 18, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alissa ArmstrongRejji Kuruvilla
Jan 1, 1980·Journal of Neurochemistry·G P Harper, H Thoenen
Jun 19, 1995·The Journal of Comparative Neurology·R H MelloniE L Holzbaur

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