PMID: 12106596Jul 11, 2002Paper

The effect of the selective 5-HT(3) receptor agonist on ferret gut motility

Life Sciences
Yukinori NagakuraTokio Yamaguchi


The effect of the selective 5-hydroxytryptamine (5-HT)(3) receptor agonist YM-31636 (2-(1H-imidazol-4-ylmethyl)-8H-indeno[1,2-d]thiazole monofumarate) on gut motility of fed ferrets was investigated. YM-31636 (0.1 mg/kg p.o.) induced a giant migrating contraction (GMC)-like, high-amplitude, ungrouped colonic contraction although it did not change the basal colonic motility pattern. This GMC-like contraction was always accompanied by defecation. Both GMC-like contraction and defecation were inhibited with the selective 5-HT(3) receptor antagonist ramosetron. YM-31636 affected gastric, duodenal and ileal motility pattern only slightly. These results suggest that 5-HT(3) receptor agonists such as YM-31636 are useful in treating constipation since they facilitate GMC-like contractions and defecation without undesired changes in gut motility pattern.


Jun 1, 1991·Digestive Diseases and Sciences·S K Sarna
Jul 1, 1991·Digestive Diseases and Sciences·S K Sarna
Apr 1, 1996·Naunyn-Schmiedeberg's Archives of Pharmacology·Y NagakuraK Miyata
Feb 19, 1997·European Journal of Pharmacology·Y NagakuraK Miyata
May 30, 1997·European Journal of Pharmacology·Y NagakuraK Miyata
Apr 2, 1999·Trends in Pharmacological Sciences·M R BriejerS K Sarna
Dec 6, 2000·European Journal of Pharmacology·H ItoT Yamaguchi

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