PMID: 12106596Jul 11, 2002Paper

The effect of the selective 5-HT(3) receptor agonist on ferret gut motility

Life Sciences
Yukinori NagakuraTokio Yamaguchi

Abstract

The effect of the selective 5-hydroxytryptamine (5-HT)(3) receptor agonist YM-31636 (2-(1H-imidazol-4-ylmethyl)-8H-indeno[1,2-d]thiazole monofumarate) on gut motility of fed ferrets was investigated. YM-31636 (0.1 mg/kg p.o.) induced a giant migrating contraction (GMC)-like, high-amplitude, ungrouped colonic contraction although it did not change the basal colonic motility pattern. This GMC-like contraction was always accompanied by defecation. Both GMC-like contraction and defecation were inhibited with the selective 5-HT(3) receptor antagonist ramosetron. YM-31636 affected gastric, duodenal and ileal motility pattern only slightly. These results suggest that 5-HT(3) receptor agonists such as YM-31636 are useful in treating constipation since they facilitate GMC-like contractions and defecation without undesired changes in gut motility pattern.

References

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Citations

Apr 13, 2007·Digestive Diseases and Sciences·Munenori NagaoIwao Sasaki
Nov 18, 2003·Alimentary Pharmacology & Therapeutics·N S ColemanR C Spiller
Apr 9, 2005·The Veterinary Clinics of North America. Exotic Animal Practice·Cathy A Johnson-Delaney
Jul 27, 2007·Journal of Pharmacological Sciences·Takuya HirataMasao Sasamata
Jul 8, 2018·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Tomoyuki OnoMichiaki Unno
May 18, 2021·Journal of Equine Veterinary Science·Alshimaa M M Farag, Hussam M M Ibrahim

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