The effect of the selective PAF antagonist BN 52021 on PAF- and antigen-induced bronchial hyper-reactivity and eosinophil accumulation

European Journal of Pharmacology
A J CoyleP Braquet

Abstract

Sensitised guinea-pigs were exposed to an aerosol of ovalbumin (100-500 micrograms/ml) and normal animals were exposed to an aerosol of platelet activating factor (PAF) (250-1000 micrograms/ml). Twenty-four hours later, bronchial reactivity was assessed by measurement of air overflow in response to i.v. histamine or acetylcholine using the Konsett-Rossler technique. Additionally, bronchoalveolar lavage was performed by washing the lungs with 10 ml of 0.9% saline and differential counts obtained to assess the ability of PAF and antigen to elicit pulmonary inflammatory cell recruitment. Both PAF and antigen exposure produced a dose-related increase in bronchial reactivity, while treatment with the vehicle (either 0.25% bovine serum albumin or 0.9% saline) had no effect on airway responsiveness. Furthermore, both PAF and antigen exposure produced a selective accumulation of eosinophils into the airways. There was no significant change in the number of neutrophils, macrophages or lymphocytes. The selective PAF antagonist BN52021 inhibited both the development of bronchial hyper-reactivity and the eosinophil influx into the airways induced by PAF or antigen exposure. These observations suggest that PAF has a central role to play in ...Continue Reading

References

Feb 1, 1986·Lancet·P J Barnes
Dec 1, 1986·The Journal of Clinical Investigation·A J WardlawA B Kay
Feb 13, 1987·Biochemical and Biophysical Research Communications·N TamuraR G Townley
Apr 1, 1987·British Journal of Pharmacology·P J BarnesD N Robertson
Sep 1, 1986·New England and Regional Allergy Proceedings·G J Gleich
Apr 1, 1986·The Journal of Allergy and Clinical Immunology·E Frigas, G J Gleich
Sep 1, 1987·British Journal of Pharmacology·D N Robertson, C P Page
May 1, 1985·Clinical Reviews in Allergy·W J MetzgerH B Richerson
Sep 1, 1985·Clinical Allergy·S R Durham, A B Kay
Jul 30, 1983·Lancet·D W Cockcroft
Sep 3, 1983·Lancet·R M Auty, A Chambers
Nov 17, 1984·Lancet·J MorleyC P Page
Nov 1, 1980·British Journal of Haematology·M ChignardJ Benveniste
Jan 1, 1986·Immunology Today·A CapronA B Tonnel

❮ Previous
Next ❯

Citations

Dec 1, 1991·Lipids·K F Chung, P J Barnes
Feb 28, 1989·European Journal of Pharmacology·L DaffonchioB J Whittle
Jan 17, 1990·European Journal of Pharmacology·H Salari, A Wong
Jul 9, 1991·European Journal of Pharmacology·T IwamaS Tanaka
Jan 7, 1992·European Journal of Pharmacology·S L UnderwoodD Raeburn
Mar 1, 1990·Journal of Pharmacological Methods·J P TarayreJ Tisne-Versailles
Aug 1, 1994·Prostaglandins, Leukotrienes, and Essential Fatty Acids·T SakuraiH Nagai
Sep 11, 1992·Respiratory Medicine·C KroegelH Matthys
Aug 28, 2004·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Leonard Bielory
Jan 1, 1990·British Journal of Clinical Pharmacology·C P Page
Sep 1, 1990·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R M Cook
Jan 1, 1991·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E BoichotP Braquet
Jan 1, 1992·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C D WegnerR H Gundel
Nov 1, 1992·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H O Heuer
Dec 1, 1993·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·V LagenteP Braquet
Jan 1, 1995·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M B Emanuel, P H Howarth
Dec 1, 1995·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L Kuitert, N C Barnes
Aug 1, 1996·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·K H Hsieh
Jan 1, 1990·Fundamental & Clinical Pharmacology·V LagenteP Braquet
Jan 1, 1992·British Journal of Pharmacology·T IwamaA Koda
Aug 1, 1992·British Journal of Pharmacology·J R Thorne, K J Broadley
Jan 1, 1991·Annals of the New York Academy of Sciences·P J Barnes

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.