PMID: 15394076Dec 1, 1949Paper

The effect of the size of the inoculum and the age of the infection on the curative dose of penicillin in experimental infections with streptococci, pneumococci, and Treponema pallidum

The Journal of Experimental Medicine
H Eagle

Abstract

The amount of penicillin which suffices to abort pneumococcal and streptococcal infections in white mice and rabbits, as well as syphilitic infection in rabbits, has been shown to increase markedly with the number of organisms inoculated. The curative dose increases also with the age of the infection, presumably owing to the interim increase in the number of organisms in the nfected host. The necessity for the larger doses of penicillin is attributed to the longer itime for which effectively bactericidal concentrations of penicillin must then be provided in order to kill the larger number of organisms.

Citations

Jun 17, 2006·Nature Reviews. Microbiology·Bruce R Levin, Daniel E Rozen
Jul 2, 1953·The New England Journal of Medicine·L W WANNAMAKERE O HAHN
Feb 17, 2009·The Journal of Antimicrobial Chemotherapy·Klas I UdekwuBruce R Levin
Sep 1, 1955·The British Journal of Venereal Diseases·T GUTHE
Mar 29, 2007·PLoS Medicine·Lynn E ConnollyLalita Ramakrishnan
Aug 22, 2007·PloS One·Andy GardnerAshleigh S Griffin
Nov 3, 2010·British Journal of Clinical Pharmacology·Jürgen B BulittaNicholas H G Holford
Jun 8, 2011·FEMS Microbiology Reviews·José L Martínez, Fernando Rojo
Sep 17, 2015·Circulation·Larry M BaddourUNKNOWN American Heart Association Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease of the Council on Cardiovascular
Feb 1, 1986·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section B, Microbiology·N Frimodt-Møller, V F Thomsen
Jan 1, 1950·Acta Pathologica Et Microbiologica Scandinavica·B FOGH
Jan 1, 2013·Antibiotics·Fernando Corona, Jose L Martinez
Jul 31, 1971·The Medical Journal of Australia·B A Smithurst
Dec 6, 1969·The Medical Journal of Australia·B A Smithurst
Jul 6, 2021·Microbiology and Immunology·Masahiro YutaniYukako Fujinaga

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