PMID: 8582130Nov 1, 1995Paper

The effect of the timing and the administration of acarbose on postprandial hyperglycaemia

Diabetic Medicine : a Journal of the British Diabetic Association
Christoph RosakU Hofmann

Abstract

To clarify the optimum timing for ingestion of acarbose, a 100 mg dose of this oral hypoglycaemic agent was administered 30 min before, at the beginning, and 15 min after ingestion of a test meal, and the effects of the drug on blood glucose rises were compared with increases observed after a control meal (no drug). Twenty-four patients with Type 2 diabetes were included in a randomized, open, cross-over study. The smallest increases in blood glucose (p < 0.001) occurred when acarbose was taken at the beginning and 15 min after starting the test meal (3.3 +/- 1.6 mmol l-1 and 3.3 +/- 1.4 mmol l-1). The increase in blood glucose levels when acarbose was taken 30 min before the test meal was significantly higher (4.2 +/- 1.8 mmol l-1) and it was at its maximum following the control meal (5.2 +/- 1.7 mmol l-1). Similar results were observed when the effects of acarbose on insulin and C-peptide levels were measured. It is recommended that patients should be instructed to take acarbose with their first mouthful of food.

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Citations

Oct 6, 1997·Endocrinology and Metabolism Clinics of North America·H E Lebovitz
Mar 2, 2002·Journal of Diabetes and Its Complications·Christoph Rosak
Oct 25, 2012·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Christoph Rosak, Gabriele Mertes
Mar 1, 2012·Expert Opinion on Drug Delivery·Ruchita V Kumar, Vivek Ranjan Sinha
Dec 26, 2008·Diabetes Research and Clinical Practice·Kazutaka AokiYasuo Terauchi
May 12, 2007·Diabetes Research and Clinical Practice·Kazutaka AokiYasuo Terauchi
Mar 17, 2004·Journal of Diabetes and Its Complications·Stephen Davis, Miriam D Alonso
Aug 11, 2015·Expert Opinion on Pharmacotherapy·Shashank R JoshiRahul Rathod
Sep 1, 2014·Expert Review of Endocrinology & Metabolism·Sanjay Kalra
Feb 4, 2021·Journal of Family Medicine and Primary Care·Sanjay KalraK Shaikh

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