The effect of the timing of exposure to Campylobacter jejuni on the gut microbiome and inflammatory responses of broiler chickens

Microbiome
P L ConnertonI F Connerton

Abstract

Campylobacters are an unwelcome member of the poultry gut microbiota in terms of food safety. The objective of this study was to compare the microbiota, inflammatory responses, and zootechnical parameters of broiler chickens not exposed to Campylobacter jejuni with those exposed either early at 6 days old or at the age commercial broiler chicken flocks are frequently observed to become colonized at 20 days old. Birds infected with Campylobacter at 20 days became cecal colonized within 2 days of exposure, whereas birds infected at 6 days of age did not show complete colonization of the sample cohort until 9 days post-infection. All birds sampled thereafter were colonized until the end of the study at 35 days (mean 6.1 log10 CFU per g of cecal contents). The cecal microbiota of birds infected with Campylobacter were significantly different to age-matched non-infected controls at 2 days post-infection, but generally, the composition of the cecal microbiota were more affected by bird age as the time post infection increased. The effects of Campylobacter colonization on the cecal microbiota were associated with reductions in the relative abundance of OTUs within the taxonomic family Lactobacillaceae and the Clostridium cluster XIVa....Continue Reading

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Citations

May 21, 2019·Journal of Pediatric Gastroenterology and Nutrition·Danielle Nicole RendinaChristopher L Coe
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Datasets Mentioned

BETA
PRJNA380214
SRP133552

Methods Mentioned

BETA
biopsies
PCR

Software Mentioned

ANOSIM
Genstat
BLASTn
Prinseq
SIMPER
GraphPad Prism
LEfSe
Mothur
R
MiSeq SOP

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