The effect of the total small vessel disease burden on the structural brain network

Scientific Reports
Xiaopei XuEdward S Hui

Abstract

Different cerebral small vessel disease (SVD) lesion types have been shown to disrupt structural brain network individually. Considering that they often coexist, we investigated the relation between their collective effect using the recently proposed total SVD score and structural brain network on MRI in 95 patients with first transient ischemic attack (TIA) or ischemic stroke. Fifty-nine patients with and 36 without any SVD lesions were included. The total SVD score was recorded. Diffusion tensor imaging was performed to estimate structural brain connections for subsequent brain connectivity analysis. The global efficiency and characteristic path length of the structural brain network are respectively lower and higher due to SVD. Lower nodal efficiency is also found in the insular, precuneus, supplementary motor area, paracentral lobule, putamen and hippocampus. The total SVD score is correlated with global network measures, the local clustering coefficient and nodal efficiency of hippocampus, and the nodal efficiency of paracentral lobule. We have successfully demonstrated that the disruption of global and local structural brain networks are associated with the increase in the overall SVD severity or burden of patients with T...Continue Reading

References

Aug 1, 1987·AJR. American Journal of Roentgenology·F FazekasR A Zimmerman
Jun 12, 1998·Nature·D J Watts, S H Strogatz
Nov 3, 2001·Physical Review Letters·V Latora, M Marchiori
Mar 18, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·V C T MokK S Wong
Oct 27, 2004·NeuroImage·Stephen M SmithPaul M Matthews
Aug 10, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Geoffrey J M Parker, Daniel C Alexander
Jan 10, 2006·Brain : a Journal of Neurology·Andrea E Cavanna, Michael R Trimble
Apr 7, 2006·The New England Journal of Medicine·Steven M Greenberg
Feb 6, 2007·PLoS Computational Biology·Sophie Achard, Ed Bullmore
Oct 18, 2007·PloS One·Olaf SpornsRolf Kötter
Feb 27, 2008·Brain : a Journal of Neurology·Yong LiuTianzi Jiang
Jul 4, 2008·PLoS Biology·Patric HagmannOlaf Sporns
Dec 9, 2008·NeuroImage·Mark W WoolrichStephen M Smith
Jan 24, 2009·Lancet Neurology·Steven M GreenbergUNKNOWN Microbleed Study Group
May 12, 2009·Neuroscience Letters·Isabella MutschlerTonio Ball
Oct 13, 2009·NeuroImage·Mikail Rubinov, Olaf Sporns
Jan 9, 2010·Stroke; a Journal of Cerebral Circulation·Fergus N DoubalJoanna M Wardlaw
Oct 12, 2010·Stroke; a Journal of Cerebral Circulation·Mariëlle M F PoelsMonique M B Breteler
Dec 17, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chun-Yi LoChing-Po Lin
Jan 22, 2011·Annals of the New York Academy of Sciences·Olaf Sporns
Jan 29, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Wei WenPerminder Sachdev
Aug 23, 2011·NeuroImage·Karlijn F de LaatFrank-Erik de Leeuw
Apr 14, 2012·Nature Reviews. Neuroscience·Ed Bullmore, Olaf Sporns
Aug 28, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·Michael K LiemJeroen van der Grond
Dec 12, 2012·Frontiers in Neuroinformatics·Jesse A BrownSusan Y Bookheimer
Jan 9, 2013·Current Opinion in Neurobiology·Olaf Sporns
May 21, 2013·Stroke; a Journal of Cerebral Circulation·Yael D ReijmerUNKNOWN Utrecht Vascular Cognitive Impairment Study Group
Jul 23, 2013·Lancet Neurology·Joanna M WardlawUNKNOWN STandards for ReportIng Vascular changes on nEuroimaging (STRIVE v1)
Aug 21, 2013·Journal of Alzheimer's Disease : JAD·Sophie M HeringaUNKNOWN Utrecht Vascular Cognitive Impairment (VCI) Study Group
Nov 1, 2013·Neurology·Saloua AkoudadMeike W Vernooij
Nov 16, 2013·Trends in Cognitive Sciences·Martijn P van den Heuvel, Olaf Sporns
Nov 26, 2013·Neuron·Costantino Iadecola
Apr 30, 2014·Frontiers of Neurology and Neuroscience·K K Moodley, D Chan
Nov 12, 2014·BMC Medicine·Johannes Attems, Kurt A Jellinger
Apr 16, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jinfu TangZhanjun Zhang
May 16, 2015·Journal of Neurology·Daniela PinterFranz Fazekas
Jul 21, 2015·Neurobiology of Aging·Julie StaalsJoanna M Wardlaw

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Citations

Jul 19, 2019·Neurorehabilitation and Neural Repair·Alexandra BasilakosJulius Fridriksson
Sep 22, 2020·Brain Communications·Eckhard SchlemmBastian Cheng
Jun 1, 2021·Frontiers in Aging Neuroscience·Xiaoshuang LiuFajin Lv
Dec 21, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Anna DewenterMarco Duering

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Software Mentioned

FMRIB Software Library ( FSL )
FMRIB Diffusion Toolbox
Diffusion Toolkit
FNIRT
FLIRT
SPSS
Brain Connectivity Toolbox

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